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Gomes F, Ashorn P, Askari S, et al. Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations. Ann N Y Acad Sci. 2022;doi: 10.1111/nyas.14733.
Gomes, F., Ashorn, P., Askari, S., Belizan, J. M., Boy, E., Cormick, G., Dickin, K. L., Driller-Colangelo, A. R., Fawzi, W., Hofmeyr, G. J., Humphrey, J., Khadilkar, A., Mandlik, R., Neufeld, L. M., Palacios, C., Roth, D. E., Shlisky, J., Sudfeld, C. R., Weaver, C., & Bourassa, M. W. (2022). Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations. Annals of the New York Academy of Sciences, . https://doi.org/10.1111/nyas.14733
Gomes, Filomena, et al. "Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations." Annals of the New York Academy of Sciences vol. (2022). doi: https://doi.org/10.1111/nyas.14733
Gomes F, Ashorn P, Askari S, Belizan JM, Boy E, Cormick G, Dickin KL, Driller-Colangelo AR, Fawzi W, Hofmeyr GJ, Humphrey J, Khadilkar A, Mandlik R, Neufeld LM, Palacios C, Roth DE, Shlisky J, Sudfeld CR, Weaver C, Bourassa MW. Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations. Ann N Y Acad Sci. 2022 Jan 08; doi: 10.1111/nyas.14733. Epub 2022 Jan 08. PMID: 35000200.
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Ann N Y Acad Sci. 2022 Jan 08; doi: 10.1111/nyas.14733. Epub 2022 Jan 08.

Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations.

Annals of the New York Academy of Sciences

Filomena Gomes, Per Ashorn, Sufia Askari, Jose M Belizan, Erick Boy, Gabriela Cormick, Katherine L Dickin, Amalia R Driller-Colangelo, Wafaie Fawzi, G Justus Hofmeyr, Jean Humphrey, Anuradha Khadilkar, Rubina Mandlik, Lynnette M Neufeld, Cristina Palacios, Daniel E Roth, Julie Shlisky, Christopher R Sudfeld, Connie Weaver, Megan W Bourassa

Affiliations

  1. Nutrition Science Program, New York Academy of Sciences, New York City, New York.
  2. NOVA Medical School, Universidade NOVA de Lisboa, Lisboa, Portugal.
  3. Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
  4. Children's Investment Fund Foundation, London, UK.
  5. Institute for Clinical Effectiveness and Health Policy/CONICET, Buenos Aires, Argentina.
  6. International Food Policy Research Institute, Washington, District of Columbia.
  7. Cornell University, Ithaca, New York.
  8. Harvard University, Cambridge, Massachusetts.
  9. Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  10. University of Botswana, Gaborone, Botswana.
  11. University of the Witwatersrand and Walter Sisulu University, Mthatha, South Africa.
  12. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  13. Hirabai Cowasji Jehangir Medical Research Institute, Pune, India.
  14. Global Alliance for Improved Nutrition, Geneva, Switzerland.
  15. Florida International University, Miami, Florida.
  16. The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
  17. Purdue University, West Lafayette, Indiana.

PMID: 35000200 DOI: 10.1111/nyas.14733

Abstract

Most low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5-2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.

© 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences.

Keywords: calcium deficiency; calcium supplementation; hypertensive disorders; preeclampsia; pregnancy

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