Scand J Immunol. 2022 Jan 09;e13140. doi: 10.1111/sji.13140. Epub 2022 Jan 09.

Hacking macrophages to combat cancer and inflammatory diseases-Current advances and challenges.

Scandinavian journal of immunology

Panagiotis F Christopoulos

PMID: 35000232 DOI: 10.1111/sji.13140

Abstract

Recently, immunotherapy has been served as the treatment of choice for various human pathophysiologies, including inflammatory diseases and cancer. Though most of the current approaches target the lymphoid compartment, macrophages intimately implicated in the induction or resolution of inflammation have rationally gained their place into the therapeutics arena. In this review, I discuss the past and novel groundbreaking strategies focusing on macrophages in different human diseases and highlight the current challenges and considerations underlying their translational potentials.

This article is protected by copyright. All rights reserved.

Keywords: autoimmunity; cancer immunotherapy; inflammation; macrophage M1/M2 polarization

Publication Types

• Journal Article
• Review