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Ghosh S, Nag S, Saha KD, et al. S-Benzyl Cysteine Based Cyclic Dipeptide Super Hydrogelator: Enhancing Efficacy of an Anticancer Drug via Sustainable Release. J Pept Sci. 2022;e3403doi: 10.1002/psc.3403.
Ghosh, S., Nag, S., Saha, K. D., & Banerji, B. (2022). S-Benzyl Cysteine Based Cyclic Dipeptide Super Hydrogelator: Enhancing Efficacy of an Anticancer Drug via Sustainable Release. Journal of peptide science : an official publication of the European Peptide Society, e3403. https://doi.org/10.1002/psc.3403
Ghosh, Saswati, et al. "S-Benzyl Cysteine Based Cyclic Dipeptide Super Hydrogelator: Enhancing Efficacy of an Anticancer Drug via Sustainable Release." Journal of peptide science : an official publication of the European Peptide Society vol. (2022): e3403. doi: https://doi.org/10.1002/psc.3403
Ghosh S, Nag S, Saha KD, Banerji B. S-Benzyl Cysteine Based Cyclic Dipeptide Super Hydrogelator: Enhancing Efficacy of an Anticancer Drug via Sustainable Release. J Pept Sci. 2022 Jan 09;e3403. doi: 10.1002/psc.3403. Epub 2022 Jan 09. PMID: 35001443.
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J Pept Sci. 2022 Jan 09;e3403. doi: 10.1002/psc.3403. Epub 2022 Jan 09.

S-Benzyl Cysteine Based Cyclic Dipeptide Super Hydrogelator: Enhancing Efficacy of an Anticancer Drug via Sustainable Release.

Journal of peptide science : an official publication of the European Peptide Society

Saswati Ghosh, Sayoni Nag, Krishna Das Saha, Biswadip Banerji

Affiliations

  1. Organic & Medicinal Chemistry Division, Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India.
  2. Cancer Biology & Inflammatory Disorder, Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India.
  3. Academy of Scientific and Innovative Research (AcSIR), Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India.

PMID: 35001443 DOI: 10.1002/psc.3403

Abstract

Peptide based low molecular weight supramolecular hydrogels hold promising aspects in various fields of application especially in biomaterial and biomedical sciences such as drug delivery, wound healing, tissue engineering, cell proliferation, etc due to their extreme biocompatibility. Unlike linear peptides, cyclic peptides have more structural rigidity and tolerance to enzymatic degradation and high environmental stability which make them even better candidates for the above said applications. Herein, a new small cyclic dipeptide (CDP) cyclo-(Leu-S-Bzl-Cys) (P1) consisting of L-leucine and S-benzyl protected L-cysteine was reported which formed hydrogel at physiological conditions (at 37

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Keywords: 5-fluorouracil; Anticancer activity; Cyclic dipeptide; Drug delivery vehicle; Nanofibrillar self-assembly; Super hydrogelator; Sustainable drug release

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