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Chen H, Cui Y, Zhang D, et al. The role of fibroblast growth factor 8 in cartilage development and disease. J Cell Mol Med. 2022;doi: 10.1111/jcmm.17174.
Chen, H., Cui, Y., Zhang, D., Xie, J., & Zhou, X. (2022). The role of fibroblast growth factor 8 in cartilage development and disease. Journal of cellular and molecular medicine, . https://doi.org/10.1111/jcmm.17174
Chen, Haoran, et al. "The role of fibroblast growth factor 8 in cartilage development and disease." Journal of cellular and molecular medicine vol. (2022). doi: https://doi.org/10.1111/jcmm.17174
Chen H, Cui Y, Zhang D, Xie J, Zhou X. The role of fibroblast growth factor 8 in cartilage development and disease. J Cell Mol Med. 2022 Jan 09; doi: 10.1111/jcmm.17174. Epub 2022 Jan 09. PMID: 35001536.
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J Cell Mol Med. 2022 Jan 09; doi: 10.1111/jcmm.17174. Epub 2022 Jan 09.

The role of fibroblast growth factor 8 in cartilage development and disease.

Journal of cellular and molecular medicine

Haoran Chen, Yujia Cui, Demao Zhang, Jing Xie, Xuedong Zhou

Affiliations

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  2. Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

PMID: 35001536 DOI: 10.1111/jcmm.17174

Abstract

Fibroblast growth factor 8 (FGF-8), also known as androgen-induced growth factor (AIGF), is presumed to be a potent mitogenic cytokine that plays important roles in early embryonic development, brain formation and limb development. In the bone environment, FGF-8 produced or received by chondrocyte precursor cells binds to fibroblast growth factor receptor (FGFR), causing different levels of activation of downstream signalling pathways, such as phospholipase C gamma (PLCγ)/Ca

© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Keywords: FGF-8; cartilage; chondrocyte; osteoarthritis; skeletal system

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