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Manikkath J, Jishnu PV, Wich PR, et al. Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis. Nanomedicine (Lond). 2022;doi: 10.2217/nnm-2021-0381.
Manikkath, J., Jishnu, P. V., Wich, P. R., Manikkath, A., & Radhakrishnan, R. (2022). Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis. Nanomedicine (London, England), . https://doi.org/10.2217/nnm-2021-0381
Manikkath, Jyothsna, et al. "Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis." Nanomedicine (London, England) vol. (2022). doi: https://doi.org/10.2217/nnm-2021-0381
Manikkath J, Jishnu PV, Wich PR, Manikkath A, Radhakrishnan R. Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis. Nanomedicine (Lond). 2022 Jan 11; doi: 10.2217/nnm-2021-0381. Epub 2022 Jan 11. PMID: 35014880.
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Nanomedicine (Lond). 2022 Jan 11; doi: 10.2217/nnm-2021-0381. Epub 2022 Jan 11.

Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis.

Nanomedicine (London, England)

Jyothsna Manikkath, Padacherri Vethil Jishnu, Peter R Wich, Aparna Manikkath, Raghu Radhakrishnan

Affiliations

  1. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
  2. Department of Cell & Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
  3. School of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
  4. Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA 94103, USA.
  5. Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

PMID: 35014880 DOI: 10.2217/nnm-2021-0381

Abstract

MicroRNAs (miRNAs) are naturally occurring noncoding RNAs with multiple functionalities. They are dysregulated in several conditions and can serve as disease biomarkers, therapeutic targets and therapeutic agents. Translation of miRNA therapeutics to the clinic poses several challenges related to the safe and effective delivery of these agents to the site of action. Nanoparticulate carriers hold promise in this area by enhancing targeting efficiency and reducing off-target effects. This paper reviews recent advances in the delivery strategies of miRNAs in anticancer therapy, with a focus on lipid-based, polymeric, inorganic platforms, cell membrane-derived vesicles and bacterial minicells. Additionally, this review explores the potentiality of miRNAs in the treatment of oral submucous fibrosis, a potentially premalignant condition of the oral cavity with no definitive treatment to date.

Keywords: cancer/oncology; gene/drug delivery; liposomes; miRNA; nanoparticles; oral cancer; oral submucous fibrosis

Publication Types

Grant support