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Bhatia R, Padma Srivastava MV, Sylaja PN, et al. Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India. Ann Indian Acad Neurol. 2021;24(5):668-685doi: 10.4103/aian.AIAN_122_21.
Bhatia, R., Padma Srivastava, M. V., Sylaja, P. N., Komakula, S., Upadhyay, A., Pardasani, V., Iype, T., Parthasarathy, R., Reddy, R., Kushwaha, S., Roy, J., Satish, P., Trikha, A., Wig, N., Dhar, L., Vibha, D., Vishnu, V. Y., Pandit, A. K., Gupta, A., Elavarasi, A., Agarwal, A., Gupta, V., Singh, R. K., Oza, H., Halani, H., Ramachandran, D., George, G. B., Panicker, P., Suresh, M. K., Kumaravelu, S., Khurana, D., Rajendran, S. P., Pamidimukkala, V., Gupta, S., Pandian, J. D., Chowdhury, D., Rai, N. K., Sharma, A., & Nambiar, V. K. (2021). Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India. Annals of Indian Academy of Neurology, 24(5), 668-685. https://doi.org/10.4103/aian.AIAN_122_21
Bhatia, Rohit, et al. "Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India." Annals of Indian Academy of Neurology vol. 24,5 (2021): 668-685. doi: https://doi.org/10.4103/aian.AIAN_122_21
Bhatia R, Padma Srivastava MV, Sylaja PN, Komakula S, Upadhyay A, Pardasani V, Iype T, Parthasarathy R, Reddy R, Kushwaha S, Roy J, Satish P, Trikha A, Wig N, Dhar L, Vibha D, Vishnu VY, Pandit AK, Gupta A, Elavarasi A, Agarwal A, Gupta V, Singh RK, Oza H, Halani H, Ramachandran D, George GB, Panicker P, Suresh MK, Kumaravelu S, Khurana D, Rajendran SP, Pamidimukkala V, Gupta S, Pandian JD, Chowdhury D, Rai NK, Sharma A, Nambiar VK. Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India. Ann Indian Acad Neurol. 2021 Sep-Oct;24(5):668-685. doi: 10.4103/aian.AIAN_122_21. Epub 2021 Aug 30. PMID: 35002124; PMCID: PMC8680894.
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Ann Indian Acad Neurol. 2021 Sep-Oct;24(5):668-685. doi: 10.4103/aian.AIAN_122_21. Epub 2021 Aug 30.

Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India.

Annals of Indian Academy of Neurology

Rohit Bhatia, M V Padma Srivastava, P N Sylaja, Snigdha Komakula, Ashish Upadhyay, Vibhor Pardasani, Thomas Iype, Rajsrinivas Parthasarathy, Rajshekhar Reddy, Suman Kushwaha, Jayanta Roy, P Satish, Anjan Trikha, Naveet Wig, Lalit Dhar, Deepti Vibha, Venugopalan Y Vishnu, Awadh Kishore Pandit, Anu Gupta, A Elavarasi, Ayush Agarwal, Vipul Gupta, Rakesh K Singh, Harsh Oza, Hiral Halani, Dileep Ramachandran, Githin B George, Praveen Panicker, M K Suresh, S Kumaravelu, Dheeraj Khurana, Srijithesh P Rajendran, Vijaya Pamidimukkala, Salil Gupta, Jeyaraj D Pandian, Debashish Chowdhury, Nirendra K Rai, Arvind Sharma, Vivek K Nambiar

Affiliations

  1. Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  2. Department of Neurology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
  3. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
  4. Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
  5. Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
  6. Department of Neurology, Artemis Hospitals, Gurgaon, Haryana, India.
  7. Department of Neurointervention Surgery, Artemis Hospitals, Gurgaon, Haryana, India.
  8. Department of Neurology, Institute of Human Behaviour and Allied Sciences, Neurology, New Delhi, India.
  9. Department of Neurology, Institute of Neurosciences, Kolkata, West Bengal, India.
  10. Department of Anaesthesia, All India Institute of Medical Sciences, New Delhi, India.
  11. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  12. Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  13. Department of Neurology, Ramesh Hospitals Guntur, Andhra Pradesh, India.
  14. Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  15. Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India.
  16. Department of Neurology, Lalitha Super Specialty Hospital, Guntur, Andhra Pradesh, India.
  17. Department of Neurology, Command Hospital Air Force Bangalore, Bangalore, Karnataka, India.
  18. Department of Neurology, Christian Medical College, Ludhiana, Punjab, India.
  19. Department of Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, Delhi, India.
  20. Department of Neurology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
  21. Department of Neurology, Zydus Hospital, Ahmedabad, Gujarat, India.
  22. Department of Neurology, Amrita Institute of Medical Sciences, Cochin, Kerala.

PMID: 35002124 PMCID: PMC8680894 DOI: 10.4103/aian.AIAN_122_21

Abstract

BACKGROUND AND PURPOSE: Occurrence of stroke has been reported among patients with COVID-19. The present study compares clinical features and outcomes of stroke patients with and without COVID-19.

METHODS: The COVID-19 Stroke Study Group (CSSG) is a multicentric study in 18 sites across India to observe and compare the clinical characteristics of patients with stroke admitted during the current pandemic period and a similar epoch in 2019. The present study reports patients of stroke with and without COVID-19 (CoVS and non-CoVS, respectively) seen between February 2020 and July 2020. Demographic, clinical, treatment, and outcome details of patients were collected.

RESULTS: The mean age and gender were comparable between the two groups. CoVS patients had higher stroke severity and extent of cerebral involvement on imaging. In-hospital complications and death were higher among CoVS patients (53.06% vs. 17.51%;

CONCLUSIONS: CoVS is associated with higher severity, poor outcome, and increased mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity are independent predictors of mortality.

Copyright: © 2006 - 2021 Annals of Indian Academy of Neurology.

Keywords: COVID-19; SARS-CoV-2; ischemic stroke; stroke; thrombolysis

Conflict of interest statement

There are no conflicts of interest.

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