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Wang HD, Zhang CS, Li MW, et al. The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis. Front Endocrinol (Lausanne). 2021;12:708139doi: 10.3389/fendo.2021.708139.
Wang, H. D., Zhang, C. S., Li, M. W., Lin, Q., Zhang, Q., Liu, D. F., Ma, Z. Y., & Dong, J. (2021). The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis. Frontiers in endocrinology, 12708139. https://doi.org/10.3389/fendo.2021.708139
Wang, Hai-Dan, et al. "The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis." Frontiers in endocrinology vol. 12 (2021): 708139. doi: https://doi.org/10.3389/fendo.2021.708139
Wang HD, Zhang CS, Li MW, Lin Q, Zhang Q, Liu DF, Ma ZY, Dong J. The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis. Front Endocrinol (Lausanne). 2021 Aug 26;12:708139. doi: 10.3389/fendo.2021.708139. eCollection 2021. PMID: 34512548; PMCID: PMC8426512.
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Front Endocrinol (Lausanne). 2021 Aug 26;12:708139. doi: 10.3389/fendo.2021.708139. eCollection 2021.

The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.

Frontiers in endocrinology

Hai-Dan Wang, Cai-Shun Zhang, Man-Wen Li, Qian Lin, Qing Zhang, De-Feng Liu, Zheng-Ye Ma, Jing Dong

Affiliations

  1. Special Medicine Department, Medical College, Qingdao University, Qingdao, China.
  2. Clinical Medicine Department, Medical College, Qingdao University, Qingdao, China.
  3. Physiology Department, Medical College, Qingdao University, Qingdao, China.

PMID: 34512548 PMCID: PMC8426512 DOI: 10.3389/fendo.2021.708139

Abstract

BACKGROUND: Insulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.

METHODS: The literature search was performed in PubMed, Embase, and Web of Science using the keywords "Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3" from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger's test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.

RESULTS: We included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39,

CONCLUSION: Trp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.

Copyright © 2021 Wang, Zhang, Li, Lin, Zhang, Liu, Ma and Dong.

Keywords: Trp64Arg; insulin resistance; meta-analysis; subgroup analysis; β3-adrenergic receptor gene

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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