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Dickstein DL, De Gasperi R, Gama Sosa MA, et al. Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure. Mol Psychiatry. 2020;26(10):5940-5954doi: 10.1038/s41380-020-0674-z.
Dickstein, D. L., De Gasperi, R., Gama Sosa, M. A., Perez-Garcia, G., Short, J. A., Sosa, H., Perez, G. M., Tschiffely, A. E., Dams-O'Connor, K., Pullman, M. Y., Knesaurek, K., Knutsen, A., Pham, D. L., Soleimani, L., Jordan, B. D., Gordon, W. A., Delman, B. N., Shumyatsky, G., Shahim, P. P., DeKosky, S. T., Stone, J. R., Peskind, E., Blennow, K., Zetterberg, H., Chance, S. A., Torso, M., Kostakoglu, L., Sano, M., Hof, P. R., Ahlers, S. T., Gandy, S., & Elder, G. A. (2021). Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure. Molecular psychiatry, 26(10), 5940-5954. https://doi.org/10.1038/s41380-020-0674-z
Dickstein, Dara L, et al. "Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure." Molecular psychiatry vol. 26,10 (2021): 5940-5954. doi: https://doi.org/10.1038/s41380-020-0674-z
Dickstein DL, De Gasperi R, Gama Sosa MA, Perez-Garcia G, Short JA, Sosa H, Perez GM, Tschiffely AE, Dams-O'Connor K, Pullman MY, Knesaurek K, Knutsen A, Pham DL, Soleimani L, Jordan BD, Gordon WA, Delman BN, Shumyatsky G, Shahim PP, DeKosky ST, Stone JR, Peskind E, Blennow K, Zetterberg H, Chance SA, Torso M, Kostakoglu L, Sano M, Hof PR, Ahlers ST, Gandy S, Elder GA. Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure. Mol Psychiatry. 2021 Oct;26(10):5940-5954. doi: 10.1038/s41380-020-0674-z. Epub 2020 Feb 25. PMID: 32094584; PMCID: PMC7484380.
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Mol Psychiatry. 2021 Oct;26(10):5940-5954. doi: 10.1038/s41380-020-0674-z. Epub 2020 Feb 25.

Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.

Molecular psychiatry

Dara L Dickstein, Rita De Gasperi, Miguel A Gama Sosa, Georgina Perez-Garcia, Jennifer A Short, Heidi Sosa, Gissel M Perez, Anna E Tschiffely, Kristen Dams-O'Connor, Mariel Y Pullman, Karin Knesaurek, Andrew Knutsen, Dzung L Pham, Lale Soleimani, Barry D Jordan, Wayne A Gordon, Bradley N Delman, Gleb Shumyatsky, Pashtun-Poh Shahim, Steven T DeKosky, James R Stone, Elaine Peskind, Kaj Blennow, Henrik Zetterberg, Steven A Chance, Mario Torso, Lale Kostakoglu, Mary Sano, Patrick R Hof, Stephen T Ahlers, Sam Gandy, Gregory A Elder

Affiliations

  1. Department of Pathology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA.
  2. Center for Neuroscience and Regenerative Medicine, Bethesda, MD, 20814, USA.
  3. Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
  4. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
  5. Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
  6. Department of Neurotrauma, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.
  7. Department of Rehabilitation and Physical Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
  8. Department of Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
  9. Burke Rehabilitation and Research, 785 Mamaroneck Avenue, White Plains, NY, 10605, USA.
  10. Department of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
  11. National Institute of Neurological Disorders and Stroke, NIH Neurological Institute, PO Box 5081, Bethesda, MD, 20824, USA.
  12. Department of Neurology, University of Florida, Gainesville, FL, 32611, USA.
  13. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VI, 2903, USA.
  14. VA Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA, 98195, USA.
  15. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, 98195, USA.
  16. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.
  17. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, S-431 80, Mölndal, Sweden.
  18. UK Dementia Research Institute at UCL, London, WC1E 6BT, UK.
  19. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  20. Nuffield Department of Clinical Neurosciences, University of Oxford, Neuropathology, West Wing, Level 1, Oxford, OX3 9DU, UK.
  21. Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  22. Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy, New York, NY, 10029, USA.
  23. Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  24. Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA. [email protected].
  25. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA. [email protected].
  26. Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA. [email protected].
  27. Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [email protected].
  28. NFL Neurological Care Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [email protected].
  29. Neurology Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA. [email protected].
  30. South Australian Health and Research Medical Institute, Adelaide, 5000, South Australia. [email protected].
  31. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA. [email protected].
  32. Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA. [email protected].
  33. Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [email protected].
  34. Neurology Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA. [email protected].

PMID: 32094584 PMCID: PMC7484380 DOI: 10.1038/s41380-020-0674-z

Abstract

Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [

© 2020. The Author(s).

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