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Xiao Q, Qian J, Evans DS, et al. Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men. J Gerontol A Biol Sci Med Sci. 2022;77(1):55-65doi: 10.1093/gerona/glab095.
Xiao, Q., Qian, J., Evans, D. S., Redline, S., Lane, N. E., Ancoli-Israel, S., Scheer, F. A. J. L., & Stone, K. (2022). Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men. The journals of gerontology. Series A, Biological sciences and medical sciences, 77(1), 55-65. https://doi.org/10.1093/gerona/glab095
Xiao, Qian, et al. "Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 77,1 (2022): 55-65. doi: https://doi.org/10.1093/gerona/glab095
Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone K. Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men. J Gerontol A Biol Sci Med Sci. 2022 Jan 07;77(1):55-65. doi: 10.1093/gerona/glab095. PMID: 33822930.
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J Gerontol A Biol Sci Med Sci. 2022 Jan 07;77(1):55-65. doi: 10.1093/gerona/glab095.

Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men.

The journals of gerontology. Series A, Biological sciences and medical sciences

Qian Xiao, Jingyi Qian, Daniel S Evans, Susan Redline, Nancy E Lane, Sonia Ancoli-Israel, Frank A J L Scheer, Katie Stone

Affiliations

  1. Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, the University of Texas Health Science Center at Houston, USA.
  2. Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  3. Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  4. Research Institute, California Pacific Medical Center, San Francisco, USA.
  5. Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  6. Department of Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, USA.
  7. Department of Psychiatry, Center for Circadian Biology, University of California San Diego, USA.

PMID: 33822930 DOI: 10.1093/gerona/glab095

Abstract

Chronic increases in pro-inflammatory cytokines in older adults, known as inflammaging, are an important risk factor for morbidity and mortality in the aging population. It has been suggested that circadian disruption may play a role in chronic inflammation, but there has been limited study that investigated the overall profile of 24-hour rest-activity rhythms in relation to inflammation using longitudinal data. In the Outcomes of Sleep Disorders in Older Men Study, we applied the extended cosine model to derive multiple rest-activity rhythm characteristics using multiday actigraphy, and examined their associations with 6 inflammatory markers (ie, C-reactive protein [CRP], interleukin 6 [IL-6], tumor necrosis factor alpha [TNF-α], tumor necrosis factor alpha soluble receptor II [TNF-α-sRII], interleukin-1β [IL-1β], interferon gamma [IFN-γ]) measured from fasting blood. We assessed both the cross-sectional association between rest-activity rhythms and inflammatory markers measured at baseline, and the prospective association between baseline rest-activity rhythms and changes in inflammatory markers over 3.5 years of follow-up. We found that multiple rest-activity characteristics, including lower amplitude and relative amplitude, and decreased overall rhythmicity, were associated with higher levels of CRP, IL-6, TNF-α, and TNF-α-sRII, but not IL-1β and IFN-γ at baseline. Moreover, the lowest quartile of these 3 rest-activity characteristics was associated with an approximately 2-fold increase in the odds of having elevated inflammation (ie, having 3 or more markers in the highest quartile) at baseline. However, we found little evidence supporting a relationship between rest-activity rhythm characteristics and changes in inflammatory markers. Future studies should clarify the dynamic relationship between rest-activity rhythms and inflammation in different populations, and evaluate the effects of improving rest-activity profiles on inflammation and related disease outcomes.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: Circadian rhythms; Inflammation; Older men; Rest; activity characteristics

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