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Baffi TR, Lordén G, Wozniak JM, et al. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021;14(678)doi: 10.1126/scisignal.abe4509.
Baffi, T. R., Lordén, G., Wozniak, J. M., Feichtner, A., Yeung, W., Kornev, A. P., King, C. C., Del Rio, J. C., Limaye, A. J., Bogomolovas, J., Gould, C. M., Chen, J., Kennedy, E. J., Kannan, N., Gonzalez, D. J., Stefan, E., Taylor, S. S., & Newton, A. C. (2021). mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science signaling, 14(678), . https://doi.org/10.1126/scisignal.abe4509
Baffi, Timothy R, et al. "mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif." Science signaling vol. 14,678 (2021). doi: https://doi.org/10.1126/scisignal.abe4509
Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 Apr 13;14(678). doi: 10.1126/scisignal.abe4509. PMID: 33850054; PMCID: PMC8208635.
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Sci Signal. 2021 Apr 13;14(678). doi: 10.1126/scisignal.abe4509.

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Science signaling

Timothy R Baffi, Gema Lordén, Jacob M Wozniak, Andreas Feichtner, Wayland Yeung, Alexandr P Kornev, Charles C King, Jason C Del Rio, Ameya J Limaye, Julius Bogomolovas, Christine M Gould, Ju Chen, Eileen J Kennedy, Natarajan Kannan, David J Gonzalez, Eduard Stefan, Susan S Taylor, Alexandra C Newton

Affiliations

  1. Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.
  2. Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA.
  3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
  4. Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innsbruck A-6020, Austria.
  5. Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
  6. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
  7. Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
  8. Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
  9. Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA.
  10. Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. [email protected].

PMID: 33850054 PMCID: PMC8208635 DOI: 10.1126/scisignal.abe4509

Abstract

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly phosphorylates this motif remains controversial. Here, we identified an mTOR-mediated phosphorylation site that we termed the TOR interaction motif (TIM; F-x

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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