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Madendağ Y, Sahin E, Col Madendag I, et al. Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses. J Perinat Med. 2021;50(1):87-92doi: 10.1515/jpm-2021-0003.
Madendağ, Y., Sahin, E., Col Madendag, I., & Eraslan Sahin, M. (2022). Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses. Journal of perinatal medicine, 50(1), 87-92. https://doi.org/10.1515/jpm-2021-0003
Madendağ, Yusuf, et al. "Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses." Journal of perinatal medicine vol. 50,1 (2022): 87-92. doi: https://doi.org/10.1515/jpm-2021-0003
Madendağ Y, Sahin E, Col Madendag I, Eraslan Sahin M. Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses. J Perinat Med. 2021 Jul 20;50(1):87-92. doi: 10.1515/jpm-2021-0003. Print 2022 Jan 27. PMID: 34280960.
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J Perinat Med. 2021 Jul 20;50(1):87-92. doi: 10.1515/jpm-2021-0003. Print 2022 Jan 27.

Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses.

Journal of perinatal medicine

Yusuf Madendağ, Erdem Sahin, Ilknur Col Madendag, Mefkure Eraslan Sahin

Affiliations

  1. Depertmant of Obstetrics and Gynecology, Erciyes University Medicine Faculty, Kayseri, Turkey.
  2. Department of Obstetrics and Gynecology, Kayseri City Hospital, Kayseri, Turkey.

PMID: 34280960 DOI: 10.1515/jpm-2021-0003

Abstract

OBJECTIVES: Considering the effects of bile-acid levels on fetal lungs and pulmonary surfactants, we hypothesized that in the presence of intrahepatic pregnancy cholestasis (ICP), poor neonatal respiratory problems are observed in relation to the severity of the disease. Delivery timing with the presence of ICP is scheduled during late-preterm and early term gestational weeks. The aim of this study was to assess ICP and disease severity effects on transient tachypnea of the newborn (TTN) in uncomplicated fetuses.

METHODS: This study comprised 1,097 singleton pregnant women who were separated into three groups-control, mild ICP, and severe ICP. The pregnant women diagnosed with ICP between January 2010 and September 2020 was investigated using the hospital's database. For the control group, healthy pregnant women who met the same exclusion criteria and were similar in terms of maternal age, gestational age at delivery, and mode of delivery were analyzed.

RESULTS: The TTN rate was 14.5% in the severe ICP group, 6.5% in the mild ICP group, and 6.2% in the control group. The TTN rate in the severe ICP group was significantly higher than that in the other groups (p<0.001). Similarly, the rate of admission to the neonatal intensive care unit was significantly higher in the severe ICP group than in the other groups (p<0.001). According to Pearson correlation analyses, maternal serum bile-acid levels were positively correlated with TTN (r=0.082; p=0.002).

CONCLUSIONS: Severe ICP, but not mild ICP, and serum bile-acid levels were positively correlated with increased TTN risk and reduced pulmonary surfactant levels.

© 2021 Walter de Gruyter GmbH, Berlin/Boston.

Keywords: bile acid levels; intrahepatic cholestasis of pregnancy (ICP); transient tachypnea of the newborn (TTN)

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