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Andreu-Pascual M, Merranko J, Gill MK, et al. Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis. J Affect Disord. 2022;300:296-304doi: 10.1016/j.jad.2022.01.003.
Andreu-Pascual, M., Merranko, J., Gill, M. K., Levenson, J. C., Hafeman, D., Hower, H., Yen, S., Strober, M., Goldstein, B. I., Diler, R., Ryan, N. D., Weinstock, L. M., Keller, M. B., Axelson, D., Birmaher, B., & Goldstein, T. R. (2022). Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis. Journal of affective disorders, 300296-304. https://doi.org/10.1016/j.jad.2022.01.003
Andreu-Pascual, Maria, et al. "Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis." Journal of affective disorders vol. 300 (2022): 296-304. doi: https://doi.org/10.1016/j.jad.2022.01.003
Andreu-Pascual M, Merranko J, Gill MK, Levenson JC, Hafeman D, Hower H, Yen S, Strober M, Goldstein BI, Diler R, Ryan ND, Weinstock LM, Keller MB, Axelson D, Birmaher B, Goldstein TR. Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis. J Affect Disord. 2022 Jan 03;300:296-304. doi: 10.1016/j.jad.2022.01.003. Epub 2022 Jan 03. PMID: 34990625.
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J Affect Disord. 2022 Jan 03;300:296-304. doi: 10.1016/j.jad.2022.01.003. Epub 2022 Jan 03.

Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis.

Journal of affective disorders

Maria Andreu-Pascual, John Merranko, Mary Kay Gill, Jessica C Levenson, Danella Hafeman, Heather Hower, Shirley Yen, Michael Strober, Benjamin I Goldstein, Rasim Diler, Neal D Ryan, Lauren M Weinstock, Martin B Keller, David Axelson, Boris Birmaher, Tina R Goldstein

Affiliations

  1. Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA; Child and Adolescent Psychiatry and Psychology Department. Hospital Sant Joan de Déu Barcelona, Spain. Passeig Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Spain. Electronic address: [email protected].
  2. Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
  3. Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Department of Health Services, Policy, and Practice, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Department of Psychiatry, School of Medicine, University of California at San Diego, 4510 Executive Drive, Suite 315, San Diego, CA 92121, USA.
  4. Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Massachusetts Mental Health Center and the Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  5. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Mail Code 175919, Los Angeles, CA 90095, USA.
  6. Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto Faculty of Medicine, 2075 Bayview Ave., FG-53, Toronto, ON M4N-3M5, Canada.
  7. Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Butler Hospital, 700 Butler Drive, Providence, RI 02906, USA.
  8. Department of Psychiatry, Nationwide Children's Hospital and The Ohio State College of Medicine, 1670 Upham Dr., Columbus, OH 43210, USA.

PMID: 34990625 DOI: 10.1016/j.jad.2022.01.003

Abstract

BACKGROUND: Childhood abuse negatively impacts the course of Bipolar Disorder (BD). Yet, no study has examined risk factors associated with prospectively evaluated physical/sexual abuse, specifically, those preceding first abuse among BD youth. We investigate past/intake/follow-up factors preceding first physical/sexual abuse among BD youth.

METHODS: Childhood-onset BD participants (n = 279 youth, mean age at intake = 12, mean length of follow-up = 12 years) enrolled in the Course and Outcome of Bipolar Youth (COBY) study. Demographic, clinical and family history variables were assessed every 7 months on average using Longitudinal Interval Follow-up Evaluation and Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL). Abuse was evaluated at intake using the K-SADS-PL, over follow-up with a Traumatic Events Screen. Family psychopathology was assessed using Family History Screen/Structured Clinical Interview for Diagnostic Statistical Manual-IV.

RESULTS: Fifteen-percent of youth reported new-onset abuse during follow-up (62% physical, 26% sexual; 12% both). Intake predictors included more severe depressive symptoms (HR = 1.29), low socioeconomic-status (SES) in families with substance abuse (HR = 0.84) (physical abuse), and female sex (HR = 2.41) (sexual abuse). Follow-up predictors preceding physical abuse included: older age (HR = 1.42), disruptive disorders (HR = 1.39), and the interaction between low SES and family substance abuse (HR = 0.86). For sexual abuse, female sex (HR = 4.33) and a non-biologically related father presence in the household (HR = 2.76). Good relationships with friends (prospectively evaluated) protected against physical/sexual abuse (HR = 0.72/0.70, respectively).

LIMITATIONS: Prospective data was gathered longitudinally but assessed retrospectively at every follow-up; perpetrator information and abuse severity were not available.

CONCLUSIONS: Identifying factors temporally preceding new onset physical/sexual abuse may hold promise for identifying high-risk youth with BD.

Copyright © 2022 Elsevier B.V. All rights reserved.

Keywords: Bipolar disorder; Physical abuse; Prospective study; Risk factor; Sexual abuse; Youth

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