Ther Drug Monit. 2022 Feb 01;44(1):32-49. doi: 10.1097/FTD.0000000000000934.
Therapeutic Drug Monitoring of Antibiotic Drugs: The Role of the Clinical Laboratory.
Therapeutic drug monitoring
Maria Shipkova, Hedi Jamoussi
Affiliations
Affiliations
- Competence Center for Therapeutic Drug Monitoring, SYNLAB Holding Germany GmbH, SYNLAB MVZ Leinfelden-Echterdingen GmbH, Leinfelden-Echterdingen, Germany.
PMID: 34726200
DOI: 10.1097/FTD.0000000000000934
Abstract
BACKGROUND: Therapeutic drug monitoring (TDM) of anti-infective drugs is an increasingly complex field, given that in addition to the patient and drug as 2 usual determinants, its success is driven by the pathogen. Pharmacodynamics is related both to the patient (toxicity) and bacterium (efficacy or antibiotic susceptibility). The specifics of TDM of antimicrobial drugs stress the need for multidisciplinary knowledge and expertise, as in any other field. The role and the responsibility of the laboratory in this interplay are both central and multifaceted. This narrative review highlights the role of the clinical laboratory in the TDM process.
METHODS: A literature search was conducted in PubMed and Google Scholar, focusing on the past 5 years (studies published since 2016) to limit redundancy with previously published review articles. Furthermore, the references cited in identified publications of interest were screened for additional relevant studies and articles.
RESULTS: The authors addressed microbiological methods to determine antibiotic susceptibility, immunochemical and chromatographic methods to measure drug concentrations (primarily in blood samples), and endogenous clinical laboratory biomarkers to monitor treatment efficacy and toxicity. The advantages and disadvantages of these methods are critically discussed, along with existing gaps and future perspectives on strategies to provide clinicians with as reliable and useful results as possible.
CONCLUSIONS: Although interest in the field has been the driver for certain progress in analytical technology and quality in recent years, laboratory professionals and commercial providers persistently encounter numerous unresolved challenges. The main tasks that need tackling include broadly and continuously available, easily operated, and cost-effective tests that offer short turnaround times, combined with reliable and easy-to-interpret results. Various fields of research are currently addressing these features.
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Conflict of interest statement
The authors declare no conflict of interest.
References
- Mabilat C, Gros MF, Nicolau D, et al. Diagnostic and medical needs for therapeutic drug monitoring of antibiotics. Eur J Clin Microbiol Infect Dis. 2020;39:791–797. - PubMed
- Roberts JA, Paul SK, Akova M, et al. DALI: defining antibiotic levels in intensive care unit patients: are current β-Lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis. 2014;58:1072–1083. - PubMed
- Blot S, Koulenti D, Akova M, et al. Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study. Crit Care. 2014;18:R99. - PubMed
- Abdulla A, Dijkstra A, Hunfeld NGM, et al. Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT). Crit Care.2020;24:558. - PubMed
- Ollivier J, Carrié C, d'Houdain N, et al. Are standard dosing regimens of ceftriaxone adapted for critically ill patients with augmented creatinine clearance? Antimicrob Agents Chemother. 2019;63:e02134-18. - PubMed
- Carrié C, Petit L, d'Houdain N, et al. Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of β-lactams administered by continuous infusion: a prospective observational study. Int J Antimicrob Agents. 2018;51:443–449. - PubMed
- Fournier A, Eggimann P, Pantet O, et al. Impact of real-time therapeutic drug monitoring on the prescription of antibiotics in burn patients requiring admission to the Intensive care unit. Antimicrob Agents Chemother. 2018;62:e01818-17. - PubMed
- Abdul-Aziz MH, Alffenaar JC, Bassetti M, et al. Antimicrobial therapeutic drug monitoring in critically ill adult patients: a position paper. Intensive Care Med. 2020;46:1127–1153. - PubMed
- Darwich AS, Polasek TM, Aronson JK, et al. Model-informed precision dosing: background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy. Annu Rev Pharmacol Toxicol. 2021;61:225–245. - PubMed
- Wicha SG, Märtson AG, Nielsen EI, et al. From therapeutic drug monitoring to model-informed precision dosing for antibiotics. Clin Pharmacol Ther. 2021;109:928–941. - PubMed
- Martínez-González NA, Keizer E, Plate A, et al. Point-of-care C-reactive protein testing to reduce antibiotic prescribing for respiratory tract infections in primary care: systematic review and meta-analysis of randomised controlled trials. Antibiotics (Basel). 2020;16:610. - PubMed
- Leicht HB, Weinig E, Mayer B, et al. Ceftriaxone-induced hemolytic anemia with severe renal failure: a case report and review of literature. BMC Pharmacol Toxicol. 2018;19:67. - PubMed
- Lee EY, Caffrey AR. Thrombocytopenia with tedizolid and linezolid. Antimicrob Agents Chemother. 2018;62:e01453-17. - PubMed
- Roberts JA, Pea F, Lipman J. The clinical relevance of plasma protein binding changes. Clin Pharmacokinet. 2013;52:1–8. - PubMed
- Self WH, Balk RA, Grijalva CG, et al. Procalcitonin as a marker of etiology in adults hospitalized with community-acquired pneumonia. Clin Infect Dis. 2017;65:183–190. - PubMed
- Fontela PS, O'Donnell S, Papenburg J. Can biomarkers improve the rational use of antibiotics? Curr Opin Infect Dis. 2018;31:347–352. - PubMed
- Petel D, Winters N, Gore GC, et al. Use of C-reactive protein to tailor antibiotic use: a systematic review and meta-analysis. BMJ Open. 2018;8:e022133. - PubMed
- Iankova I, Thompson-Leduc P, Kirson NY, et al. Efficacy and safety of procalcitonin guidance in patients with suspected or confirmed sepsis: a systematic review and meta-analysis. Crit Care Med. 2018;46:691–698. - PubMed
- Meier MA, Branche A, Neeser OL, et al. Procalcitonin-guided antibiotic treatment in patients with positive blood cultures: a patient-level meta-analysis of randomized trials. Clin Infect Dis. 2019;69:388–396. - PubMed
- Wirz Y, Meier MA, Bouadma L, et al. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit Care. 2018;22:191. - PubMed
- Heffernan AJ, Denny KJ. Host diagnostic biomarkers of infection in the ICU: where are we and where are we going? Curr Infect Dis Rep. 2021;23:4. - PubMed
- Scharf C, Paal M, Schroeder I, et al. Therapeutic drug monitoring of meropenem and piperacillin in critical illness-experience and recommendations from one year in routine clinical practice. Antibiotics (Basel). 2020;9:131. - PubMed
- Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clin Chim Acta. 2005;351:17–29. - PubMed
- Williams P, Cotta MO, Roberts JA. Pharmacokinetics/pharmacodynamics of β-Lactams and therapeutic drug monitoring: from theory to practical issues in the intensive care unit. Semin Respir Crit Care Med. 2019;40:476–487. - PubMed
- Bragadottir G, Redfors B, Ricksten SE. Assessing glomerular filtration rate (GFR) in critically ill patients with acute kidney injury—true GFR versus urinary creatinine clearance and estimating equations. Crit Care. 2013;17:R108. - PubMed
- Casu GS, Hites M, Jacobs F, et al. Can changes in renal function predict variations in β-lactam concentrations in septic patients? Int J Antimicrob Agents. 2013;42:422–428. - PubMed
- Sunder S, Jayaraman R, Mahapatra HS, et al. Estimation of renal function in the intensive care unit: the covert concepts brought to light. J Intensive Care. 2014;2:31. - PubMed
- Weidhase L, Wellhöfer D, Schulze G, et al. Is interleukin-6 a better predictor of successful antibiotic therapy than procalcitonin and C-reactive protein? A single center study in critically ill adults. BMC Infect Dis. 2019;19:150. - PubMed
- Molano Franco D, Arevalo-Rodriguez I, Roqué I Figuls M, et al. Plasma interleukin‐6 concentration for the diagnosis of sepsis in critically ill adults. Cochrane Database Syst Rev. 2019;4:CD011811. - PubMed
- Hung SK, Lan HM, Han ST, et al. Current evidence and limitation of biomarkers for detecting sepsis and systemic infection. Biomedicines. 2020;8:494. - PubMed
- Hombach M, Ochoa C, Maurer FP, et al. Relative contribution of biological variation and technical variables to zone diameter variations of disc diffusion susceptibility testing. J Antimicrob Chemother. 2016;71:141–151. - PubMed
- Mouton JW, Meletiadis J, Voss A, et al. Variation of MIC measurements: the contribution of strain and laboratory variability to measurement precision. J Antimicrob Chemother. 2018;73:2374–2379. - PubMed
- Mulroney KT, Hall JM, Huang X, et al. Rapid susceptibility profiling of carbapenem-resistant Klebsiella pneumoniae. Sci Rep. 2017;7:1903. - PubMed
- Machen A, Drake T, Wang YF. Same day identification and full panel antimicrobial susceptibility testing of bacteria from positive blood culture bottles made possible by a combined lysis-filtration method with MALDI-TOF VITEK mass spectrometry and the VITEK2 system. PLoS One. 2014;9:e87870. - PubMed
- Lagacé-Wiens PR, Adam HJ, Karlowsky JA, et al. Identification of blood culture isolates directly from positive blood cultures by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry and a commercial extraction system: analysis of performance, cost, and turnaround time. J Clin Microbiol. 2012;50:3324–3328. - PubMed
- Ferreira L, Sánchez-Juanes F, González-Avila M, et al. Direct identification of urinary tract pathogens from urine samples by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2010;48:2110–2115. - PubMed
- Griffin PM, Price GR, Schooneveldt JM, et al. Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry to identify vancomycin-resistant enterococci and investigate the epidemiology of an outbreak. J Clin Microbiol. 2012;50:2918–2931. - PubMed
- Nix ID, Idelevich EA, Storck LM, et al. Detection of methicillin resistance in Staphylococcus aureus from agar cultures and directly from positive blood cultures using MALDI-TOF mass spectrometry-based direct-on-target microdroplet growth assay. Front Microbiol. 2020;11:232. - PubMed
- Sparbier K, Schubert S, Weller U, et al. Matrix-assisted laser desorption ionization-time of flight mass spectrometry-based functional assay for rapid detection of resistance against β-lactam antibiotics. J Clin Microbiol. 2012;50:927–937. - PubMed
- Hrabák J, Studentová V, Walková R, et al. Detection of NDM-1, VIM-1, KPC, OXA-48, and OXA-162 carbapenemases by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2012;50:2441–2443. - PubMed
- Carvalhaes CG, Cayô R, Visconde MF, et al. Detection of carbapenemase activity directly from blood culture vials using MALDI-TOF MS: a quick answer for the right decision. J Antimicrob Chemother. 2014;69:2132–2136. - PubMed
- Chong PM, McCorrister SJ, Unger MS, et al. MALDI-TOF MS detection of carbapenemase activity in clinical isolates of Enterobacteriaceae spp., Pseudomonas aeruginosa, and Acinetobacter baumannii compared against the Carba-NP assay. J Microbiol Methods. 2015;111:21–23. - PubMed
- Nagy E, Becker S, Sóki J, et al. Differentiation of division I (cfiA-negative) and division II (cfiA-positive) Bacteroides fragilis strains by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Med Microbiol. 2011;60:1584–1590. - PubMed
- Fenyvesi VS, Urbán E, Bartha N, et al. Use of MALDI-TOF/MS for routine detection of cfiA gene-positive Bacteroides fragilis strains Int J Antimicrob Agents. 2014;44:474–475. - PubMed
- Josten M, Dischinger J, Szekat C, et al. Identification of agr-positive methicillin-resistant Staphylococcus aureus harbouring the class A mec complex by MALDI-TOF mass spectrometry. Int J Antimicrob Agents. 2014;304:1018–1023. - PubMed
- Khan ZA, Siddiqui MF, Park S. Current and emerging methods of antibiotic susceptibility testing. Diagnostics (Basel). 2019;9:49. - PubMed
- Hombach M, Zbinden R, Böttger EC. Standardisation of disk diffusion results for antibiotic susceptibility testing using the sirscan automated zone reader. BMC Microbiol. 2013;13:225. - PubMed
- Chen CH, Lu Y, Sin ML, et al. Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels. Anal Chem. 2010;82:1012–1019. - PubMed
- Baltekin Ö, Boucharin A, Tano E, et al. Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging. Proc Natl Acad Sci U S A. 2017;114:9170–9175. - PubMed
- Marques SM, Esteves da Silva JC. Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions. IUBMB Life. 2009;61:6–17. - PubMed
- Dong T, Zhao X. Rapid identification and susceptibility testing of uropathogenic microbes via immunosorbent ATP-bioluminescence assay on a microfluidic simulator for antibiotic therapy. Anal Chem. 2015;87:2410–2418. - PubMed
- Ivancic V, Mastali M, Percy N, et al. Rapid antimicrobial susceptibility determination of uropathogens in clinical urine specimens by use of ATP bioluminescence. J Clin Microbiol. 2008;46:1213–1219. - PubMed
- Peck Palmer OM, Dasgupta A. A review of the preanalytical errors that impact therapeutic drug monitoring. Ther Drug Monit. 2021; 43:595–608. - PubMed
- Traugott KA, Maxwell PR, Green K, et al. Effects of therapeutic drug monitoring criteria in a computerized prescriber-order-entry system on the appropriateness of vancomycin level orders. Am J Health Syst Pharm. 2011;68:347–352. - PubMed
- Van Vooren S, Verstraete AG. A sensitive and high-throughput quantitative liquid chromatography high-resolution mass spectrometry method for therapeutic drug monitoring of 10 β-lactam antibiotics, linezolid and two β-lactamase inhibitors in human plasma. Biomed Chromatogr. 2021;35:e5092. - PubMed
- Lefeuvre S, Bois-Maublanc J, Hocqueloux L, et al. A simple ultra-high-performance liquid chromatography-high resolution mass spectrometry assay for the simultaneous quantification of 15 antibiotics in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1065-1066:50–58. - PubMed
- Rehm S, Rentsch KM. A 2D HPLC-MS/MS method for several antibiotics in blood plasma, plasma water, and diverse tissue samples. Anal Bioanal Chem. 2020;412:715–725. - PubMed
- Decosterd LA, Mercier T, Ternon B, et al. Validation and clinical application of a multiplex high performance liquid chromatography—tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections. J Chromatogr B Analyt Technol Biomed Life Sci. 2020;1157:122160. - PubMed
- Panda BK, Bargaje M, Sathiyanarayanan L. A simple and reliable analytical method for simultaneous quantification of first line antitubercular drugs in human plasma by LCMS/MS. Anal Methods. 2020;12:3909–3917. - PubMed
- Tsai IL, Sun HY, Chen GY, et al. Simultaneous quantification of antimicrobial agents for multidrug-resistant bacterial infections in human plasma by ultra-high-pressure liquid chromatography-tandem mass spectrometry. Talanta. 2013;116:593–603. - PubMed
- Baietto L, D'Avolio A, Ariaudo A, et al. Development and validation of a new UPLC-PDA method to quantify linezolid in plasma and in dried plasma spots. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;936:42–47. - PubMed
- Abdulla A, Bahmany S, Wijma RA, et al. Simultaneous determination of nine β-lactam antibiotics in human plasma by an ultrafast hydrophilic-interaction chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1060:138–143. - PubMed
- Tindula RJ, Ambrose PJ, Harralson AF. Aminoglycoside inactivation by penicillins and cephalosporins and its impact on drug-level monitoring. Drug Intell Clin Pharm. 1983;17:906–908. - PubMed
- Pickering LK, Rutherford I. Effect of concentration and time upon inactivation of tobramycin, gentamicin, netilmicin and amikacin by azlocillin, carbenicillin, mecillinam, mezlocillin and piperacillin. J Pharmacol Exp Ther. 1981;217:345–349. - PubMed
- Zander J, Maier B, Zoller M, et al. Effects of biobanking conditions on six antibiotic substances in human serum assessed by a novel evaluation protocol. Clin Chem Lab Med. 2016;54:265–274. - PubMed
- McConeghy KW, Liao S, Clark D, et al. Variability in telavancin cross-reactivity among vancomycin immunoassays. Antimicrob Agents Chemother. 2014;58:7093–7097. - PubMed
- Shipkova M, Petrova DT, Rosler AE, et al. Comparability and imprecision of 8 frequently used commercially available immunoassays for therapeutic drug monitoring. Ther Drug Monit.2014;36:433–441. - PubMed
- Li M, Ma L, Chen C, et al. Evaluation of assays to measure aminoglycosides in serum: comparison of accuracy and precision based on external quality assessment. Ther Drug Monit. 2020;42:710–715. - PubMed
- Castoldi S, Cozzi V, Baldelli S, et al. Comparison of the ARK immunoassay with high-performance liquid chromatography with ultraviolet detection for therapeutic drug monitoring of linezolid. Ther Drug Monit. 2018;40:140–143. - PubMed
- Brozmanová H, Kacířová I, Uřinovská R, et al. New liquid chromatography-tandem mass spectrometry method for routine TDM of vancomycin in patients with both normal and impaired renal functions and comparison with results of polarization fluoroimmunoassay in light of varying creatinine concentrations. Clin Chim Acta. 2017;469:136–143. - PubMed
- Hoppentocht M, Akkeman OW, Voerman AJ, et al. Optimisation of the sensitivity of an immunoassay analysis for tobramycin in serum. J Appl Bioanal. 2015; 1:123–127. - PubMed
- Stankowicz MS, Ibrahim J, Brown DL. Once-daily aminoglycoside dosing: an update on current literature. Am J Health Syst Pharm. 2015;72:1357–1364. - PubMed
- Singer B, Stevens RW, Westley BP, et al. Falsely elevated vancomycin-concentration values from enzyme immunoassay leading to treatment failure. Am J Health Syst Pharm. 2020;77:9–13. - PubMed
- LeGatt DF, Blakney GB, Higgins TN, et al. The effect of paraproteins and rheumatoid factor on four commercial immunoassays for vancomycin: implications for laboratorians and other health care professionals. Ther Drug Monit. 2012;34:306–311. - PubMed
- Gunther M, Saxinger L, Gray M, et al. Two suspected cases of immunoglobulin-mediated interference causing falsely low vancomycin concentrations with the Beckman PETINIA method. Ann Pharmacother. 2013;47:e19. - PubMed
- Florin L, Vantilborgh A, Pauwels S, et al. IgM interference in the Abbott iVanco immunoassay: a case report. Clin Chim Acta. 2015;447:32–33. - PubMed
- Tate J, Ward G. Interferences in immunoassay. Clin Biochem Rev. 2004;25:105–120. - PubMed
- Dijkstra JA, Voerman AJ, Greijdanus B, et al. Immunoassay analysis of kanamycin in serum using the tobramycin kit. Antimicrob Agents Chemother. 2016;60:4646–4651. - PubMed
- Fridlund J, Woksepp H, Schön T. A microbiological method for determining serum levels of broad spectrum β-lactam antibiotics in critically ill patients. J Microbiol Methods. 2016;129:23–27. - PubMed
- Toullec L, Dupouey J, Vigne C, et al. Analytical interference during cefepime therapeutic drug monitoring in intensive care patient: about a case report. Therapie. 2017;72:587–592. - PubMed
- Rigo-Bonnin R, Ribera A, Arbiol-Roca A, et al. Development and validation of a measurement procedure based on ultra-high performance liquid chromatography-tandem mass spectrometry for simultaneous measurement of β-lactam antibiotic concentration in human plasma. Clin Chim Acta. 2017;468:215–224. - PubMed
- Kai M, Tanaka R, Suzuki Y, et al. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method. Clin Biochem. 2021;90:40–49. - PubMed
- Shipkova M, Svinarov D. LC–MS/MS as a tool for TDM services: where are we? Clin Biochem. 2016;49:1009–1023. - PubMed
- Veringa A, Sturkenboom MGG, Dekkers BGJ, et al. LC-MS/MS for therapeutic drug monitoring of anti-infective drugs. Trends Analyt Chem. 2016;84:34–40. - PubMed
- Caro YS, Cámara MS, De Zan MM. A review of bioanalytical methods for the therapeutic drug monitoring of β-lactam antibiotics in critically ill patients: evaluation of the approaches used to develop and validate quality attributes. Talanta. 2020;210:120619. - PubMed
- Carlier M, Stove V, Wallis SC, et al. Assays for therapeutic drug monitoring of β-lactam antibiotics: a structured review. Int J Antimicrob Agents. 2015;46:367–375. - PubMed
- Popowicz ND, O'Halloran SJ, Fitzgerald D, et al. A rapid, LC-MS/MS assay for quantification of piperacillin and tazobactam in human plasma and pleural fluid; application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1081-1082:58–66. - PubMed
- Zander J, Maier B, Zoller M, et al. Quantification of linezolid in serum by LC-MS/MS using semi-automated sample preparation and isotope dilution internal standardization. Clin Chem Lab Med. 2014;52:381–389. - PubMed
- Sakurai N, Nakamura Y, Kawaguchi H, et al. Measurement of linezolid and its metabolites PNU-142300 and PNU-142586 in human plasma using ultra-performance liquid chromatography method. Chem Pharm Bull (Tokyo). 2019;67:439–444. - PubMed
- Kiang TK, Schmitt V, Ensom MH, et al. Therapeutic drug monitoring in interstitial fluid: a feasibility study using a comprehensive panel of drugs. J Pharm Sci. 2012;101:4642–4652. - PubMed
- Kiriazopoulos E, Zaharaki S, Vonaparti A, et al. Quantification of three beta-lactam antibiotics in breast milk and human plasma by hydrophilic interaction liquid chromatography/positive-ion electrospray ionization mass spectrometry. Drug Test Anal. 2017;9:1062–1072. - PubMed
- Zhang M, Moore GA, Chin PKL, et al. Simultaneous determination of cefalexin, cefazolin, flucloxacillin, and probenecid by liquid chromatography-tandem mass spectrometry for total and unbound concentrations in human plasma. Ther Drug Monit. 2018;40:682–692. - PubMed
- Lee K, Jun SH, Han M, et al. Multiplex assay of second-line anti-tuberculosis drugs in dried blood spots using ultra-performance liquid chromatography-tandem mass spectrometry. Ann Lab Med. 2016;36:489–493. - PubMed
- Barco S, Castagnola E, Moscatelli A, et al. Volumetric adsorptive microsampling-liquid chromatography tandem mass spectrometry assay for the simultaneous quantification of four antibiotics in human blood: method development, validation and comparison with dried blood spot. J Pharm Biomed Anal. 2017;145:704–710. - PubMed
- Moorthy GS, Vedar C, Zane NR, et al. Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrometry method for the analysis of cefepime in human whole blood: application to pediatric pharmacokinetic study. J Pharm Biomed Anal. 2020;179:113002. - PubMed
- Attia AK, Al-Ghobashy MA, El-Sayed GM, et al. Voltammetric monitoring of linezolid, meropenem and theophylline in plasma. Anal Biochem. 2018;545:54–64. - PubMed
- Carlier M, Athanasopoulos A, Borrey D, et al. Proficiency testing for meropenem and piperacillin therapeutic drug monitoring: preliminary results from the Belgian society on infectiology and clinical microbiology pharmacokinetic-pharmacodynamic working group. Ther Drug Monit. 2018;40:156–158. - PubMed
- Wallenburg E, Brüggemann RJ, Asouit K, et al. First international quality control programme for laboratories measuring antimicrobial drugs to support dose individualization in critically ill patients. J Antimicrob Chemother. 2021;76:430–433. - PubMed
- Schuster C, Sterz S, Teupser D, et al. Multiplex therapeutic drug monitoring by isotope-dilution HPLC-MS/MS of antibiotics in critical illnesses. J Vis Exp. 2018;58148. - PubMed
- Bruch R, Chatelle C, Kling A, et al. Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy. Sci Rep. 2017;7:3127. - PubMed
- Bian S, Zhu B, Rong G, et al. Towards wearable and implantable continuous drug monitoring: a review. J Pharm Anal. 2021;11:1–14. - PubMed
- Garzón V, Bustos RH, Pinacho GD. Personalized medicine for antibiotics: the role of nanobiosensors in therapeutic drug monitoring. J Pers Med. 2020;10:147. - PubMed
- Ates HC, Roberts JA, Lipman J, et al. On-site therapeutic drug monitoring. Trends Biotechnol. 2020;38:1262–1277. - PubMed
- Dorofaeff T, Bandini RM, Lipman J, et al. Uncertainty in antibiotic dosing in critically ill neonate and pediatric patients: can microsampling provide the answers? Clin Ther. 2016;38:1961–1975. - PubMed
- van den Elsen SHJ, Oostenbrink LM, Heysell SK, et al. Systematic review of salivary versus blood concentrations of antituberculosis drugs and their potential for salivary therapeutic drug monitoring. Ther Drug Monit. 2018;40:17–37. - PubMed
- van den Elsen SHJ, Akkerman OW, Jongedijk EM, et al. Therapeutic drug monitoring using saliva as matrix: an opportunity for linezolid, but challenge for moxifloxacin. Eur Respir J. 2020;55:1901903. - PubMed
- Brasier N, Widmer A, Osthoff M, et al. Non-invasive drug monitoring of β-lactam antibiotics using sweat analysis—a pilot study. Front Med (Lausanne). 2020;7:476. - PubMed
- Richter D, Weigand M. β-lactam microneedle array biosensors: a new technology on the horizon. Lancet Digit Health. 2019;1:e320–e321. - PubMed
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