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Petropoulos IN, Fitzgerald KC, Oakley J, et al. Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis. Sci Rep. 2021;11(1):21688doi: 10.1038/s41598-021-01226-1.
Petropoulos, I. N., Fitzgerald, K. C., Oakley, J., Ponirakis, G., Khan, A., Gad, H., George, P., Deleu, D., Canibano, B. G., Akhtar, N., Shuaib, A., Own, A., Malik, T., Russakoff, D. B., Mankowski, J. L., Misra, S. L., McGhee, C. N. J., Calabresi, P., Saidha, S., Kamran, S., & Malik, R. A. (2021). Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis. Scientific reports, 11(1), 21688. https://doi.org/10.1038/s41598-021-01226-1
Petropoulos, Ioannis N, et al. "Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis." Scientific reports vol. 11,1 (2021): 21688. doi: https://doi.org/10.1038/s41598-021-01226-1
Petropoulos IN, Fitzgerald KC, Oakley J, Ponirakis G, Khan A, Gad H, George P, Deleu D, Canibano BG, Akhtar N, Shuaib A, Own A, Malik T, Russakoff DB, Mankowski JL, Misra SL, McGhee CNJ, Calabresi P, Saidha S, Kamran S, Malik RA. Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis. Sci Rep. 2021 Nov 04;11(1):21688. doi: 10.1038/s41598-021-01226-1. PMID: 34737384; PMCID: PMC8568943.
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Sci Rep. 2021 Nov 04;11(1):21688. doi: 10.1038/s41598-021-01226-1.

Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis.

Scientific reports

Ioannis N Petropoulos, Kathryn C Fitzgerald, Jonathan Oakley, Georgios Ponirakis, Adnan Khan, Hoda Gad, Pooja George, Dirk Deleu, Beatriz G Canibano, Naveed Akhtar, Ashfaq Shuaib, Ahmed Own, Taimur Malik, Daniel B Russakoff, Joseph L Mankowski, Stuti L Misra, Charles N J McGhee, Peter Calabresi, Shiv Saidha, Saadat Kamran, Rayaz A Malik

Affiliations

  1. Research Division, Qatar Foundation, Weill Cornell Medicine-Qatar of Cornell University, PO Box 24144, Education City, Doha, Qatar.
  2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  3. Voxeleron LLC, San Francisco, CA, USA.
  4. Neuroscience Institute, Hamad General Hospital, Doha, Qatar.
  5. Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  6. Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  7. Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
  8. Research Division, Qatar Foundation, Weill Cornell Medicine-Qatar of Cornell University, PO Box 24144, Education City, Doha, Qatar. [email protected].

PMID: 34737384 PMCID: PMC8568943 DOI: 10.1038/s41598-021-01226-1

Abstract

Axonal loss is the main determinant of disease progression in multiple sclerosis (MS). This study aimed to assess the utility of corneal confocal microscopy (CCM) in detecting corneal axonal loss in different courses of MS. The results were confirmed by two independent segmentation methods. 72 subjects (144 eyes) [(clinically isolated syndrome (n = 9); relapsing-remitting MS (n = 20); secondary-progressive MS (n = 22); and age-matched, healthy controls (n = 21)] underwent CCM and assessment of their disability status. Two independent algorithms (ACCMetrics; and Voxeleron deepNerve) were used to quantify corneal nerve fiber density (CNFD) (ACCMetrics only), corneal nerve fiber length (CNFL) and corneal nerve fractal dimension (CNFrD). Data are expressed as mean ± standard deviation with 95% confidence interval (CI). Compared to controls, patients with MS had significantly lower CNFD (34.76 ± 5.57 vs. 19.85 ± 6.75 fibers/mm

© 2021. The Author(s).

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