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Wixler V, Zaytsev IZ, Leite Dantas R, et al. Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance. Mol Ther. 2021;doi: 10.1016/j.ymthe.2021.08.030.
Wixler, V., Zaytsev, I. Z., Leite Dantas, R., Schied, T., Boergeling, Y., Lührmann, V., Varga, G., Masemann, D., & Ludwig, S. (2021). Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance. Molecular therapy : the journal of the American Society of Gene Therapy, . https://doi.org/10.1016/j.ymthe.2021.08.030
Wixler, Viktor, et al. "Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance." Molecular therapy : the journal of the American Society of Gene Therapy vol. (2021). doi: https://doi.org/10.1016/j.ymthe.2021.08.030
Wixler V, Zaytsev IZ, Leite Dantas R, Schied T, Boergeling Y, Lührmann V, Varga G, Masemann D, Ludwig S. Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance. Mol Ther. 2021 Aug 25; doi: 10.1016/j.ymthe.2021.08.030. Epub 2021 Aug 25. PMID: 34450252.
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Mol Ther. 2021 Aug 25; doi: 10.1016/j.ymthe.2021.08.030. Epub 2021 Aug 25.

Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance.

Molecular therapy : the journal of the American Society of Gene Therapy

Viktor Wixler, Igor Z Zaytsev, Rafael Leite Dantas, Tanja Schied, Yvonne Boergeling, Veronika Lührmann, Georg Varga, Dörthe Masemann, Stephan Ludwig

Affiliations

  1. Institute of Molecular Virology, Centre for Molecular Biology of Inflammation, Westfaelische Wilhelms-University, 48149 Muenster, Germany. Electronic address: [email protected].
  2. Institute of Pharmaceutical Technologies (IPT), 121353 Moscow, Russian Federation.
  3. Institute of Molecular Virology, Centre for Molecular Biology of Inflammation, Westfaelische Wilhelms-University, 48149 Muenster, Germany.
  4. Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, 48149 Muenster, Germany.
  5. Institute of Molecular Virology, Centre for Molecular Biology of Inflammation, Westfaelische Wilhelms-University, 48149 Muenster, Germany. Electronic address: [email protected].

PMID: 34450252 DOI: 10.1016/j.ymthe.2021.08.030

Abstract

The major challenge in the treatment of autoimmune diseases is the restoration of the impaired peripheral immune tolerance that always accompanies the development of such diseases. Here, we show that small splenic peptides (SSPs) of whole spleen extract efficiently suppress the development of psoriatic arthritis in vivo, even in the presence of sustained levels of pro-inflammatory cytokines. SSPs target dendritic cells (DCs) and convert them into tolerogenic cells, which in turn differentiate naive CD4

Copyright © 2021 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Keywords: Foxp3; TNF-α; autoimmune disease; dendritic cells; peripheral tolerance; regulatory T cells

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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