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Kohno Y, Mizuno M, Endo K, et al. Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis. Tissue Cell. 2022;75:101727doi: 10.1016/j.tice.2021.101727.
Kohno, Y., Mizuno, M., Endo, K., Ozeki, N., Katano, H., Matsumoto, M., Kaneko, H., Takazawa, Y., Koga, H., & Sekiya, I. (2022). Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis. Tissue & cell, 75101727. https://doi.org/10.1016/j.tice.2021.101727
Kohno, Yuji, et al. "Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis." Tissue & cell vol. 75 (2022): 101727. doi: https://doi.org/10.1016/j.tice.2021.101727
Kohno Y, Mizuno M, Endo K, Ozeki N, Katano H, Matsumoto M, Kaneko H, Takazawa Y, Koga H, Sekiya I. Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis. Tissue Cell. 2022 Jan 04;75:101727. doi: 10.1016/j.tice.2021.101727. Epub 2022 Jan 04. PMID: 34998163.
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Tissue Cell. 2022 Jan 04;75:101727. doi: 10.1016/j.tice.2021.101727. Epub 2022 Jan 04.

Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis.

Tissue & cell

Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya

Affiliations

  1. Center for Stem Cells and Regenerative Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  2. Department of Orthopaedics, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.
  3. Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  4. Center for Stem Cells and Regenerative Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. Electronic address: [email protected].

PMID: 34998163 DOI: 10.1016/j.tice.2021.101727

Abstract

The yield of primary synovial mesenchymal stromal cells (MSCs) from synovium of patients with rheumatoid arthritis (RA) is highly variable, but cell transplantation therapy with autologous synovial MSCs requires accurate prediction of the synovial MSC yield per synovium weight. Here, we determined whether the yield of synovial fluid MSCs might predict the ultimate yield of primary MSCs from the synovium of RA knees. Synovial fluid and synovium were harvested during total knee arthroplasty from the knee joints of 10 patients with RA. Synovial fluid (1.5 mL) was diluted fourfold and plated equally into six 60 cm

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords: Mesenchymal stromal cell; Rheumatoid arthritis; Synovial fluid; Synovium; Yield

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