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Laurila S, Rebelos E, Lahesmaa M, et al. Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function. Am J Physiol Endocrinol Metab. 2021;322(1):E54-E62doi: 10.1152/ajpendo.00260.2021.
Laurila, S., Rebelos, E., Lahesmaa, M., Sun, L., Schnabl, K., Peltomaa, T. M., Klén, R., U-Din, M., Honka, M. J., Eskola, O., Kirjavainen, A. K., Nummenmaa, L., Klingenspor, M., Virtanen, K. A., & Nuutila, P. (2022). Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function. American journal of physiology. Endocrinology and metabolism, 322(1), E54-E62. https://doi.org/10.1152/ajpendo.00260.2021
Laurila, Sanna, et al. "Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function." American journal of physiology. Endocrinology and metabolism vol. 322,1 (2022): E54-E62. doi: https://doi.org/10.1152/ajpendo.00260.2021
Laurila S, Rebelos E, Lahesmaa M, Sun L, Schnabl K, Peltomaa TM, Klén R, U-Din M, Honka MJ, Eskola O, Kirjavainen AK, Nummenmaa L, Klingenspor M, Virtanen KA, Nuutila P. Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function. Am J Physiol Endocrinol Metab. 2022 Jan 01;322(1):E54-E62. doi: 10.1152/ajpendo.00260.2021. Epub 2021 Nov 22. PMID: 34806426.
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Am J Physiol Endocrinol Metab. 2022 Jan 01;322(1):E54-E62. doi: 10.1152/ajpendo.00260.2021. Epub 2021 Nov 22.

Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function.

American journal of physiology. Endocrinology and metabolism

Sanna Laurila, Eleni Rebelos, Minna Lahesmaa, Lihua Sun, Katharina Schnabl, Tia-Mari Peltomaa, Riku Klén, Mueez U-Din, Miikka-Juhani Honka, Olli Eskola, Anna K Kirjavainen, Lauri Nummenmaa, Martin Klingenspor, Kirsi A Virtanen, Pirjo Nuutila

Affiliations

  1. Turku PET Centre, University of Turku, Turku, Finland.
  2. Heart Center, Turku University Hospital, Turku, Finland.
  3. Heart Center, Satakunta Central Hospital, Pori, Finland.
  4. Department of Internal Medicine, Jorvi Hospital, Helsinki University Hospital, Helsinki, Finland.
  5. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
  6. EKFZ - Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
  7. ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.
  8. Turku PET Centre, Turku University Hospital, Turku, Finland.
  9. Department of Psychology, University of Turku, Turku, Finland.
  10. Institute of Public Health and Clinical Nutrition, University of Eastern Finland (UEF), Kuopio, Finland.
  11. Department of Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland.
  12. Department of Endocrinology, Turku University Hospital, Turku, Finland.

PMID: 34806426 DOI: 10.1152/ajpendo.00260.2021

Abstract

The cardiac benefits of gastrointestinal hormones have been of interest in recent years. The aim of this study was to explore the myocardial and renal effects of the gastrointestinal hormone secretin in the GUTBAT trial (NCT03290846). A placebo-controlled crossover study was conducted on 15 healthy males in fasting conditions, where subjects were blinded to the intervention. Myocardial glucose uptake was measured with [

Keywords: gastrointestinal hormone; kidney function; myocardial metabolism; secretin

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