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Pol J Microbiol. 2021 Dec;70(4):501-509. doi: 10.33073/pjm-2021-047. Epub 2021 Dec 23.

Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer.

Polish journal of microbiology

Felipe Ortiz-Gutiérrez, Lilia Sánchez-Minutti, José F Martínez-Herrera, Indiana D Torres-Escobar, Elias B Pezzat-Said, Luis Márquez-Domínguez, Amado I Grandes-Blanco

Affiliations

  1. Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía. Instituto Politécnico Nacional, CDMX, México.
  2. Laboratorio de Procesos Biotecnológicos, Universidad Politécnica de Tlaxcala, Tlaxcala, México.
  3. Oncología Médica y Neoplasias de Torax y Medicina Interna Centro de Cáncer Hospital ABC, CDMX, México.
  4. Facultad de Medicina, Benemerita Universidad Autónoma de Puebla, Puebla, México.
  5. Departamento de Investigación en Salud SSEP, Puebla, México.
  6. Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México.
  7. Facultad de Ciencias de la Salud, Licenciatura en Nutrición, Universidad Autónoma de Tlaxcala, Tlaxcala, México.

PMID: 35003280 PMCID: PMC8702602 DOI: 10.33073/pjm-2021-047

Abstract

Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most prevalent L1 capsid protein mutations in the HPV genotype were analyzed

© 2021 Felipe Ortiz-Gutiérrez et al.

Keywords: cervical cancer; human immunodeficiency virus; human papillomavirus; polymorphism

Conflict of interest statement

Conflict of interest The authors do not report any financial or personal connections with other persons or organizations, which might negatively affect the contents of this publication and/or claim au

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