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Pediatr Infect Dis J. 2022 Feb 01;41(2):e54-e57. doi: 10.1097/INF.0000000000003418.

Successful Treatment of a Balamuthia mandrillaris Cerebral Abscess in a Pediatric Patient With Complete Surgical Resection and Antimicrobial Therapy.

The Pediatric infectious disease journal

Joshua A Cuoco, Brendan J Klein, David P LeBel, Jason Faulhaber, Lisa S Apfel, Mark R Witcher

Affiliations

  1. From the Department of Surgery, Section of Neurosurgery, Carilion Clinic, Roanoke, Virginia.
  2. Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
  3. School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
  4. Dominion Pathology Associations, Roanoke, Virginia.
  5. Department of Infectious Diseases, Carilion Clinic, Roanoke, Virginia.

PMID: 34862343 DOI: 10.1097/INF.0000000000003418

Abstract

Cerebral amebic encephalitis due to Balamuthia mandrillaris is a rare yet typically fatal disease. As such, identification of the clinical characteristics, appropriate diagnostic workup and commencement of treatment is frequently delayed. Here, we present a case of a 4-year-old male with a B. mandrillaris cerebral abscess successfully treated with expedited neurosurgical resection and broad-spectrum antimicrobial therapy.

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

  1. Qvarnstrom Y, Visvesvara GS, Sriram R, et al. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol. 2006;44:3589–3595. - PubMed
  2. Deetz TR, Sawyer MH, Billman G, et al. Successful treatment of Balamuthia amoebic encephalitis: presentation of 2 cases. Clin Infect Dis. 2003;37:1304–1312. - PubMed
  3. Jung S, Schelper RL, Visvesvara GS, et al. Balamuthia mandrillaris meningoencephalitis in an immunocompetent patient: an unusual clinical course and a favorable outcome. Arch Pathol Lab Med. 2004;128:466–468. - PubMed
  4. Schuster FL, Yagi S, Gavali S, et al. Under the radar: balamuthia amebic encephalitis. Clin Infect Dis. 2009;48:879–887. - PubMed
  5. Martínez DY, Seas C, Bravo F, et al. Successful treatment of Balamuthia mandrillaris amoebic infection with extensive neurological and cutaneous involvement. Clin Infect Dis. 2010;51:e7–e11. - PubMed
  6. Cary LC, Maul E, Potter C, et al. Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient. Pediatrics. 2010;125:e699–e703. - PubMed
  7. Orozco LD, Khan MA, Fratkin JD, et al. Asymptomatic aneurysm of the cavernous and supraclinoid internal carotid artery in a patient with Balamuthia mandrillaris encephalitis. J Clin Neurosci. 2011;18:1118–1120. - PubMed
  8. Doyle JS, Campbell E, Fuller A, et al. Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy. J Neurosurg. 2011;114:458–462. - PubMed
  9. Moriarty P, Burke C, McCrossin D, et al. Balamuthia mandrillaris Encephalitis: survival of a child with severe meningoencephalitis and review of the literature. J Pediatric Infect Dis Soc. 2014;3:e4–e9. - PubMed
  10. Vollmer ME, Glaser C. A Balamuthia survivor. JMM Case Rep. 2016;3:e005031. - PubMed

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