Display options
Cite
Nemenov MI, Alaverdyan H, Burk C, et al. Characterization of Patients With and Without Painful Peripheral Neuropathy After Receiving Neurotoxic Chemotherapy: Traditional Quantitative Sensory Testing vs C-Fiber and Aδ-Fiber Selective Diode Laser Stimulation. J Pain. 2021;doi: 10.1016/j.jpain.2021.11.011.
Nemenov, M. I., Alaverdyan, H., Burk, C., Roles, K., Frey, K., Yan, Y., Kazinets, G., & Haroutounian, S. (2021). Characterization of Patients With and Without Painful Peripheral Neuropathy After Receiving Neurotoxic Chemotherapy: Traditional Quantitative Sensory Testing vs C-Fiber and Aδ-Fiber Selective Diode Laser Stimulation. The journal of pain, . https://doi.org/10.1016/j.jpain.2021.11.011
Nemenov, Mikhail I, et al. "Characterization of Patients With and Without Painful Peripheral Neuropathy After Receiving Neurotoxic Chemotherapy: Traditional Quantitative Sensory Testing vs C-Fiber and Aδ-Fiber Selective Diode Laser Stimulation." The journal of pain vol. (2021). doi: https://doi.org/10.1016/j.jpain.2021.11.011
Nemenov MI, Alaverdyan H, Burk C, Roles K, Frey K, Yan Y, Kazinets G, Haroutounian S. Characterization of Patients With and Without Painful Peripheral Neuropathy After Receiving Neurotoxic Chemotherapy: Traditional Quantitative Sensory Testing vs C-Fiber and Aδ-Fiber Selective Diode Laser Stimulation. J Pain. 2021 Dec 09; doi: 10.1016/j.jpain.2021.11.011. Epub 2021 Dec 09. PMID: 34896646.
Copy Download .nbib Format: NLM
Share it on

J Pain. 2021 Dec 09; doi: 10.1016/j.jpain.2021.11.011. Epub 2021 Dec 09.

Characterization of Patients With and Without Painful Peripheral Neuropathy After Receiving Neurotoxic Chemotherapy: Traditional Quantitative Sensory Testing vs C-Fiber and Aδ-Fiber Selective Diode Laser Stimulation.

The journal of pain

Mikhail I Nemenov, Harutyun Alaverdyan, Carrie Burk, Kristen Roles, Karen Frey, Yan Yan, Gene Kazinets, Simon Haroutounian

Affiliations

  1. LasMed, Mountain View, California; Department of Anesthesiology, Stanford University, Stanford, California.
  2. Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
  3. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
  4. LasMed, Mountain View, California.
  5. Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri. Electronic address: [email protected].

PMID: 34896646 DOI: 10.1016/j.jpain.2021.11.011

Abstract

Painful chemotherapy induced peripheral neuropathy (CIPN) is a common complication of chemotherapy with drugs such as taxanes and platinum compounds. Currently, no methods are available for early detection of sensory changes that are associated with painful CIPN, nor are there biomarkers that are specific to painful CIPN. This study aimed to compare Diode Laser fiber type-selective stimulator (DLss), a method to selectively stimulate cutaneous C and Aδ fibers, to traditional quantitative sensory testing (QST) in determining psychophysical differences between patients with painful CIPN and a control group. Sensory testing was performed on the dorsal mid-foot of 20 patients with painful neuropathy after taxane- or platinum-based chemotherapy, and 20 patients who received similar neurotoxic chemotherapy, without painful CIPN. In a multivariable analysis, C-fiber to Aδ fiber detection threshold ratio, measured by DLss, was significantly different between the groups (P <.05). While QST parameters such as warmth detection threshold were different between the groups in univariate analyses, these findings were likely attributable to group differences in patient age and cumulative chemotherapy dose. PERSPECTIVE: In this study, fiber-specific DLss test showed potential in identifying sensory changes that are specific for painful neuropathy, encouraging future testing of this approach as a biomarker for early detection of painful CIPN. TRIAL REGISTRATION: The study was approved by the Washington University Institutional Review Board (#201807162) and registered at ClinicalTrials.gov (NCT03687970).

Copyright © 2021 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.

Keywords: DLss stimulation; QST; neuropathic pain; painful CIPN; peripheral neuropathy

Publication Types

Grant support