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Knudsen AD, Graff C, Nielsen JB, et al. De novo electrocardiographic abnormalities in persons living with HIV. Sci Rep. 2021;11(1):20750doi: 10.1038/s41598-021-00290-x.
Knudsen, A. D., Graff, C., Nielsen, J. B., Thomsen, M. T., Høgh, J., Benfield, T., Gerstoft, J., Køber, L., Kofoed, K. F., & Nielsen, S. D. (2021). De novo electrocardiographic abnormalities in persons living with HIV. Scientific reports, 11(1), 20750. https://doi.org/10.1038/s41598-021-00290-x
Knudsen, Andreas D, et al. "De novo electrocardiographic abnormalities in persons living with HIV." Scientific reports vol. 11,1 (2021): 20750. doi: https://doi.org/10.1038/s41598-021-00290-x
Knudsen AD, Graff C, Nielsen JB, Thomsen MT, Høgh J, Benfield T, Gerstoft J, Køber L, Kofoed KF, Nielsen SD. De novo electrocardiographic abnormalities in persons living with HIV. Sci Rep. 2021 Oct 21;11(1):20750. doi: 10.1038/s41598-021-00290-x. PMID: 34675281; PMCID: PMC8531322.
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Sci Rep. 2021 Oct 21;11(1):20750. doi: 10.1038/s41598-021-00290-x.

De novo electrocardiographic abnormalities in persons living with HIV.

Scientific reports

Andreas D Knudsen, Claus Graff, Jonas Bille Nielsen, Magda Teresa Thomsen, Julie Høgh, Thomas Benfield, Jan Gerstoft, Lars Køber, Klaus F Kofoed, Susanne D Nielsen

Affiliations

  1. Viro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Blegdamsvej 9B, 2100, Copenhagen, Denmark.
  2. Department of Cardiology, The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  3. Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
  4. Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
  5. Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  6. Viro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Blegdamsvej 9B, 2100, Copenhagen, Denmark. [email protected].

PMID: 34675281 PMCID: PMC8531322 DOI: 10.1038/s41598-021-00290-x

Abstract

Persons living with HIV (PLWH) may have increased incidence of cardiovascular events and longer QTc intervals than uninfected persons. We aimed to investigate the incidence and risk factors of de novo major electrocardiogram (ECG) abnormalities and QTc prolongation in well-treated PLWH. We included virologically suppressed PLWH without major ECG abnormalities, who attended the 2-year follow-up in the Copenhagen comorbidity in HIV infection (COCOMO) study. ECGs were categorized according to Minnesota Code Manual. We defined de novo major ECG abnormalities as new major Minnesota Code Manual abnormalities. Prolonged QTc was defined as QTc > 460 ms in females and QTc > 450 ms in males. Of 667 PLWH without major ECG abnormalities at baseline, 34 (5%) developed de novo major ECG abnormalities after a median of 2.3 years. After adjustment, age (RR: 1.57 [1.08-2.28] per decade older), being underweight (RR: 5.79 [1.70-19.71]), current smoking (RR: 2.34 [1.06-5.16]), diabetes (RR: 3.89 [1.72-8.80]) and protease inhibitor use (RR: 2.45 [1.27-4.74) were associated with higher risk of getting de novo major ECG abnormalities. Of PLWH without prolonged QTc at baseline, only 11 (1.6%) participants developed de novo prolonged QTc. Five percent of well-treated PLWH acquired de novo major ECG abnormalities and protease inhibitor use was associated with more than twice the risk of de novo major ECG abnormalities. De novo prolonged QTc was rare and did not seem to constitute a problem in well-treated PLWH.

© 2021. The Author(s).

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