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Chiavaroli V, Hopkins SA, Biggs JB, et al. The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years. Sci Rep. 2021;11(1):20865doi: 10.1038/s41598-021-99869-7.
Chiavaroli, V., Hopkins, S. A., Biggs, J. B., Rodrigues, R. O., Seneviratne, S. N., Baldi, J. C., McCowan, L. M. E., Cutfield, W. S., Hofman, P. L., & Derraik, J. G. B. (2021). The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years. Scientific reports, 11(1), 20865. https://doi.org/10.1038/s41598-021-99869-7
Chiavaroli, Valentina, et al. "The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years." Scientific reports vol. 11,1 (2021): 20865. doi: https://doi.org/10.1038/s41598-021-99869-7
Chiavaroli V, Hopkins SA, Biggs JB, Rodrigues RO, Seneviratne SN, Baldi JC, McCowan LME, Cutfield WS, Hofman PL, Derraik JGB. The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years. Sci Rep. 2021 Oct 21;11(1):20865. doi: 10.1038/s41598-021-99869-7. PMID: 34675369; PMCID: PMC8531053.
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Sci Rep. 2021 Oct 21;11(1):20865. doi: 10.1038/s41598-021-99869-7.

The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years.

Scientific reports

Valentina Chiavaroli, Sarah A Hopkins, Janene B Biggs, Raquel O Rodrigues, Sumudu N Seneviratne, James C Baldi, Lesley M E McCowan, Wayne S Cutfield, Paul L Hofman, José G B Derraik

Affiliations

  1. Liggins Institute, University of Auckland, Auckland, New Zealand.
  2. Neonatal Intensive Care Unit, Pescara Public Hospital, Pescara, Italy.
  3. Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  4. Department of Health, Behavior and Society, College of Public Health, University of Kentucky, Lexington, KY, USA.
  5. Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  6. Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
  7. Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  8. A Better Start-National Science Challenge, University of Auckland, Auckland, New Zealand.
  9. Liggins Institute, University of Auckland, Auckland, New Zealand. [email protected].
  10. Liggins Institute, University of Auckland, Auckland, New Zealand. [email protected].
  11. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. [email protected].
  12. Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand. [email protected].

PMID: 34675369 PMCID: PMC8531053 DOI: 10.1038/s41598-021-99869-7

Abstract

In secondary analyses of a randomised controlled trial of exercise during pregnancy, we examined associations between mid-pregnancy maternal body mass index (BMI) and excessive gestational weight gain (GWG) with offspring health. Follow-up data were available on 57 mother-child pairs at 1-year and 52 pairs at 7-year follow-ups. Clinical assessments included body composition and fasting blood tests. At age 1 year, increased maternal BMI in mid-gestation was associated with greater weight standard deviation scores (SDS) in the offspring (p = 0.035), with no observed associations for excessive GWG. At age 7 years, greater maternal BMI was associated with increased weight SDS (p < 0.001), BMI SDS (p = 0.005), and total body fat percentage (p = 0.037) in their children. Irrespective of maternal BMI, children born to mothers with excessive GWG had greater abdominal adiposity (p = 0.043) and less favourable lipid profile (lower HDL-C and higher triglycerides). At 7 years, maternal BMI and excessive GWG had compounded adverse associations with offspring adiposity. Compared to offspring of mothers with overweight/obesity plus excessive GWG, children of normal-weight mothers with adequate and excessive GWG were 0.97 and 0.64 SDS lighter (p = 0.002 and p = 0.014, respectively), and 0.98 and 0.63 SDS leaner (p = 0.001 and p = 0.014, respectively). Both greater maternal BMI in mid-pregnancy and excessive GWG were independently associated with increased adiposity in offspring at 7 years.

© 2021. The Author(s).

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