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Immunity. 2022 Jan 11;55(1):98-114.e5. doi: 10.1016/j.immuni.2021.11.017. Epub 2021 Dec 20.

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8.

Immunity

Changwei Peng, Matthew A Huggins, Kelsey M Wanhainen, Todd P Knutson, Hanbin Lu, Hristo Georgiev, Kristen L Mittelsteadt, Nicholas N Jarjour, Haiguang Wang, Kristin A Hogquist, Daniel J Campbell, Henrique Borges da Silva, Stephen C Jameson

Affiliations

  1. Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
  2. Minnesota Supercomputing Institute, University of Minnesota, Saint Paul, MN 55108, USA.
  3. Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  4. Benaroya Research Institute and Department of Immunology University of Washington School of Medicine, Seattle, WA 98101, USA.
  5. Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: [email protected].

PMID: 34932944 DOI: 10.1016/j.immuni.2021.11.017

Abstract

Elevated gene expression of the costimulatory receptor Icos is a hallmark of CD8

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: ICOS; PI3K; resident memory T cells

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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