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Shiers S, Elahi H, Hennen S, et al. Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. Neurobiol Pain. 2021;11:100081doi: 10.1016/j.ynpai.2021.100081.
Shiers, S., Elahi, H., Hennen, S., & Price, T. J. (2022). Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. Neurobiology of pain (Cambridge, Mass.), 11100081. https://doi.org/10.1016/j.ynpai.2021.100081
Shiers, Stephanie, et al. "Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy." Neurobiology of pain (Cambridge, Mass.) vol. 11 (2022): 100081. doi: https://doi.org/10.1016/j.ynpai.2021.100081
Shiers S, Elahi H, Hennen S, Price TJ. Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. Neurobiol Pain. 2021 Dec 21;11:100081. doi: 10.1016/j.ynpai.2021.100081. eCollection 2022. PMID: 35005298; PMCID: PMC8715370.
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Neurobiol Pain. 2021 Dec 21;11:100081. doi: 10.1016/j.ynpai.2021.100081. eCollection 2022.

Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy.

Neurobiology of pain (Cambridge, Mass.)

Stephanie Shiers, Hajira Elahi, Stephanie Hennen, Theodore J Price

Affiliations

  1. The University of Texas at Dallas, Center for Advanced Pain Studies and Department of Neuroscience, Richardson, TX, USA.
  2. Grünenthal GmbH, Aachen, Germany.

PMID: 35005298 PMCID: PMC8715370 DOI: 10.1016/j.ynpai.2021.100081

Abstract

The anterior cingulate cortex (ACC) is a critical region of the brain for the emotional and affective components of pain in rodents and humans. Hyperactivity in this region has been observed in neuropathic pain states in both patients and animal models and ablation of this region from cingulotomy, or inhibition with genetics or pharmacology can diminish pain and anxiety. Two adenylyl cyclases (AC), AC1 and AC8 play an important role in regulating nociception and anxiety-like behaviors through an action in the ACC, as genetic and pharmacological targeting of these enzymes reduces mechanical hypersensitivity and anxiety-like behavior, respectively. However, the distribution of these ACs in the ACC has not been studied in the context of neuropathic pain. To address this gap in knowledge, we conducted RNAscope

© 2021 The Author(s).

Keywords: AC1; AC8; Adenylyl cycles; Neuropathic pain

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper other than that SH is an emplo

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