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Ma CH, Chou WC, Wu CH, et al. Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms. Antioxidants (Basel). 2021;10(12)doi: 10.3390/antiox10121972.
Ma, C. H., Chou, W. C., Wu, C. H., Jou, I. M., Tu, Y. K., Hsieh, P. L., & Tsai, K. L. (2021). Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms. Antioxidants (Basel, Switzerland), 10(12), . https://doi.org/10.3390/antiox10121972
Ma, Ching-Hou, et al. "Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms." Antioxidants (Basel, Switzerland) vol. 10,12 (2021). doi: https://doi.org/10.3390/antiox10121972
Ma CH, Chou WC, Wu CH, Jou IM, Tu YK, Hsieh PL, Tsai KL. Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms. Antioxidants (Basel). 2021 Dec 10;10(12). doi: 10.3390/antiox10121972. PMID: 34943075; PMCID: PMC8750552.
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Antioxidants (Basel). 2021 Dec 10;10(12). doi: 10.3390/antiox10121972.

Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms.

Antioxidants (Basel, Switzerland)

Ching-Hou Ma, Wan-Ching Chou, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Pei-Ling Hsieh, Kun-Ling Tsai

Affiliations

  1. Department of Orthopedics, E-Da Hospital, Kaohsiung City 824, Taiwan.
  2. School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung City 824, Taiwan.
  3. Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
  4. Department of Anatomy, School of Medicine, China Medical University, Taichung 404, Taiwan.
  5. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.

PMID: 34943075 PMCID: PMC8750552 DOI: 10.3390/antiox10121972

Abstract

The upregulation of tumor necrosis factor-alpha (TNF-α) is a common event in arthritis, and the subsequent signaling cascade that leads to tissue damage has become the research focus. To explore a potential therapeutic strategy to prevent cartilage degradation, we tested the effect of ginsenoside Rg3, a bioactive component of

Keywords: SIRT1; apoptosis; chondrocytes; ginsenoside Rg3; inflammation

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