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Urdinguio RG, Tejedor JR, Fernández-Sanjurjo M, et al. Physical exercise shapes the mouse brain epigenome. Mol Metab. 2021;54:101398doi: 10.1016/j.molmet.2021.101398.
Urdinguio, R. G., Tejedor, J. R., Fernández-Sanjurjo, M., Pérez, R. F., Peñarroya, A., Ferrero, C., Codina-Martínez, H., Díez-Planelles, C., Pinto-Hernández, P., Castilla-Silgado, J., Coto-Vilcapoma, A., Díez-Robles, S., Blanco-Agudín, N., Tomás-Zapico, C., Iglesias-Gutiérrez, E., Fernández-García, B., Fernandez, A. F., & Fraga, M. F. (2021). Physical exercise shapes the mouse brain epigenome. Molecular metabolism, 54101398. https://doi.org/10.1016/j.molmet.2021.101398
Urdinguio, Rocío G, et al. "Physical exercise shapes the mouse brain epigenome." Molecular metabolism vol. 54 (2021): 101398. doi: https://doi.org/10.1016/j.molmet.2021.101398
Urdinguio RG, Tejedor JR, Fernández-Sanjurjo M, Pérez RF, Peñarroya A, Ferrero C, Codina-Martínez H, Díez-Planelles C, Pinto-Hernández P, Castilla-Silgado J, Coto-Vilcapoma A, Díez-Robles S, Blanco-Agudín N, Tomás-Zapico C, Iglesias-Gutiérrez E, Fernández-García B, Fernandez AF, Fraga MF. Physical exercise shapes the mouse brain epigenome. Mol Metab. 2021 Dec;54:101398. doi: 10.1016/j.molmet.2021.101398. Epub 2021 Nov 18. PMID: 34801767; PMCID: PMC8661702.
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Mol Metab. 2021 Dec;54:101398. doi: 10.1016/j.molmet.2021.101398. Epub 2021 Nov 18.

Physical exercise shapes the mouse brain epigenome.

Molecular metabolism

Rocío G Urdinguio, Juan Ramon Tejedor, Manuel Fernández-Sanjurjo, Raúl F Pérez, Alfonso Peñarroya, Cecilia Ferrero, Helena Codina-Martínez, Carlos Díez-Planelles, Paola Pinto-Hernández, Juan Castilla-Silgado, Almudena Coto-Vilcapoma, Sergio Díez-Robles, Noelia Blanco-Agudín, Cristina Tomás-Zapico, Eduardo Iglesias-Gutiérrez, Benjamín Fernández-García, Agustin F Fernandez, Mario F Fraga

Affiliations

  1. Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, Spain.
  2. Departamento de Biología Funcional, Fisiología, Universidad de Oviedo, Oviedo 33006, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo 33011, Spain.
  3. Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo 33011, Spain; Departamento de Morfología y Biología Celular, Universidad de Oviedo, Oviedo 33006, Spain.
  4. Departamento de Biología Funcional, Fisiología, Universidad de Oviedo, Oviedo 33006, Spain.
  5. Departamento de Biología Funcional, Fisiología, Universidad de Oviedo, Oviedo 33006, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo 33011, Spain. Electronic address: [email protected].
  6. Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, Spain. Electronic address: [email protected].
  7. Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, Spain; Department of Organisms and Systems Biology (B.O.S), University of Oviedo, 33011 Oviedo, Asturias, Spain. Electronic address: [email protected].

PMID: 34801767 PMCID: PMC8661702 DOI: 10.1016/j.molmet.2021.101398

Abstract

OBJECTIVE: To analyze the genome-wide epigenomic and transcriptomic changes induced by long term resistance or endurance training in the hippocampus of wild-type mice.

METHODS: We performed whole-genome bisulfite sequencing (WGBS) and RNA sequencing (RNA-seq) of mice hippocampus after 4 weeks of specific training. In addition, we used a novel object recognition test before and after the intervention to determine whether the exercise led to an improvement in cognitive function.

RESULTS: Although the majority of DNA methylation changes identified in this study were training-model specific, most were associated with hypomethylation and were enriched in similar histone marks, chromatin states, and transcription factor biding sites. It is worth highlighting the significant association found between the loss of DNA methylation in Tet1 binding sites and gene expression changes, indicating the importance of these epigenomic changes in transcriptional regulation. However, endurance and resistance training activate different gene pathways, those being associated with neuroplasticity in the case of endurance exercise, and interferon response pathways in the case of resistance exercise, which also appears to be associated with improved learning and memory functions.

CONCLUSIONS: Our results help both understand the molecular mechanisms by which different exercise models exert beneficial effects for brain health and provide new potential therapeutic targets for future research.

Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.

Keywords: Endurance training; Epigenome; Exercise; Hippocampus; Neuroplasticity; Resistance training; Transcriptome

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