Display options
Cite
Napolitano G, Bucci I, Di Dalmazi G, et al. Non-Conventional Clinical Uses of TSH Receptor Antibodies: The Case of Chronic Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2021;12:769084doi: 10.3389/fendo.2021.769084.
Napolitano, G., Bucci, I., Di Dalmazi, G., & Giuliani, C. (2021). Non-Conventional Clinical Uses of TSH Receptor Antibodies: The Case of Chronic Autoimmune Thyroiditis. Frontiers in endocrinology, 12769084. https://doi.org/10.3389/fendo.2021.769084
Napolitano, Giorgio, et al. "Non-Conventional Clinical Uses of TSH Receptor Antibodies: The Case of Chronic Autoimmune Thyroiditis." Frontiers in endocrinology vol. 12 (2021): 769084. doi: https://doi.org/10.3389/fendo.2021.769084
Napolitano G, Bucci I, Di Dalmazi G, Giuliani C. Non-Conventional Clinical Uses of TSH Receptor Antibodies: The Case of Chronic Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2021 Nov 05;12:769084. doi: 10.3389/fendo.2021.769084. eCollection 2021. PMID: 34803929; PMCID: PMC8602826.
Copy Download .nbib Format: NLM
Share it on

Front Endocrinol (Lausanne). 2021 Nov 05;12:769084. doi: 10.3389/fendo.2021.769084. eCollection 2021.

Non-Conventional Clinical Uses of TSH Receptor Antibodies: The Case of Chronic Autoimmune Thyroiditis.

Frontiers in endocrinology

Giorgio Napolitano, Ines Bucci, Giulia Di Dalmazi, Cesidio Giuliani

Affiliations

  1. Department of Medicine and Sciences of Aging, Unit of Endocrinology, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
  2. Center for Advanced Studies and Technology (CAST), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.

PMID: 34803929 PMCID: PMC8602826 DOI: 10.3389/fendo.2021.769084

Abstract

Anti TSH receptor antibodies (TSHrAb) are a family of antibodies with different activity, some of them stimulating thyroid function (TSAb), others with blocking properties (TBAb), it is a common finding that antibodies with different function might coexist in the same patient and can modulate the function of the thyroid. However, most of the labs routinely detect all antibodies binding to the TSH receptor (TRAb, i.e. TSH-receptor antibodies detected by binding assay without definition of functional property). Classical use of TSHr-Ab assay is in Graves' disease where they are tested for diagnostic and prognostic issues; however, they can be used in specific settings of chronic autoimmune thyroiditis (CAT) as well. Aim of the present paper is to highlight these conditions where detection of TSHr-Ab can be of clinical relevance. Prevalence of TSHrAb is different in in the 2 main form of CAT, i.e. classical Hashimoto's thyroiditis and in atrophic thyroiditis, where TBAb play a major role. Simultaneous presence of both TSAb and TBAb in the serum of the same patient might have clinical implication and cause the shift from hyperthyroidism to hypothyroidism and vice versa. Evaluation of TRAb is recommended in case of patients with Thyroid Associated Orbitopathy not associated with hyperthyroidism. At present, however, the most relevant recommendation for the use of TRAb assay is in patients with CAT secondary to a known agent; in particular, after treatment with alemtuzumab for multiple sclerosis. In conclusion, the routine use of anti-TSH receptor antibodies (either TRAb or TSAb/TBAb) assay cannot be suggested at the present for diagnosis/follow up of patients affected by CAT; there are, however, several conditions where their detection can be clinically relevant.

Copyright © 2021 Napolitano, Bucci, Di Dalmazi and Giuliani.

Keywords: Hashimoto’s thyroiditis (HT); TSH-receptor blocking antibodies; TSH-receptor stimulating antibodies; atrophic thyroiditis; chronic autoimmune thyroiditis

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Eur Thyroid J. 2018 Aug;7(4):167-186 - PubMed
  2. Clin Exp Immunol. 2017 Sep;189(3):304-309 - PubMed
  3. Endocr J. 2011;58(5):343-8 - PubMed
  4. N Engl J Med. 1980 Sep 25;303(13):738-41 - PubMed
  5. Thyroid. 2011 Jun;21(6):593-646 - PubMed
  6. Front Endocrinol (Lausanne). 2016 Jul 25;7:103 - PubMed
  7. Lancet. 1966 Sep 3;2(7462):512-4 - PubMed
  8. Lancet. 2012 Nov 24;380(9856):1829-39 - PubMed
  9. Clin Endocrinol (Oxf). 1990 Dec;33(6):687-98 - PubMed
  10. J Clin Endocrinol Metab. 2017 Jan 1;102(1):6-9 - PubMed
  11. Thyroid. 2010 Mar;20(3):287-90 - PubMed
  12. J Clin Endocrinol Metab. 2009 Dec;94(12):4742-8 - PubMed
  13. Leukemia. 2004 Mar;18(3):484-90 - PubMed
  14. Lancet. 2012 Nov 24;380(9856):1819-28 - PubMed
  15. Clin Exp Immunol. 2013 Sep;173(3):390-7 - PubMed
  16. Lancet. 2014 Nov 8;384(9955):1684-90 - PubMed
  17. Expert Rev Clin Immunol. 2008 Mar;4(2):221-37 - PubMed
  18. N Engl J Med. 1992 Feb 20;326(8):513-8 - PubMed
  19. Eur Thyroid J. 2019 Jul;8(4):173-185 - PubMed
  20. J Clin Endocrinol Metab. 2016 May;101(5):1998-2004 - PubMed
  21. Mayo Clin Proc. 1971 Oct;46(10):682-9 - PubMed
  22. Autoimmun Rev. 2014 Apr-May;13(4-5):391-7 - PubMed
  23. PLoS One. 2018 Jan 8;13(1):e0190425 - PubMed
  24. Clin Endocrinol (Oxf). 2010 Sep;73(3):404-12 - PubMed
  25. Arthritis Rheum. 2001 Sep;44(9):1998-2008 - PubMed
  26. Clin Endocrinol (Oxf). 2012 Sep;77(3):465-70 - PubMed
  27. Autoimmun Rev. 2010 Aug;9(10):695-700 - PubMed
  28. J Clin Endocrinol Metab. 2014 Jan;99(1):80-9 - PubMed
  29. J Clin Endocrinol Metab. 2012 Jul;97(7):E1080-7 - PubMed
  30. Autoimmun Rev. 2009 Dec;9(2):113-6 - PubMed
  31. Clin Pediatr Endocrinol. 2021;30(2):79-84 - PubMed
  32. Horm Metab Res. 2015 Sep;47(10):727-34 - PubMed
  33. J Clin Invest. 1983 Oct;72(4):1352-6 - PubMed
  34. Thyroid. 2002 May;12(5):393-8 - PubMed
  35. Front Endocrinol (Lausanne). 2017 Jun 30;8:137 - PubMed
  36. Eur J Endocrinol. 2021 Aug 27;185(4):G43-G67 - PubMed
  37. Thyroid. 2018 Dec;28(12):1682-1693 - PubMed
  38. Biochem Biophys Res Commun. 1989 Dec 29;165(3):1184-90 - PubMed
  39. J Clin Endocrinol Metab. 1990 Jul;71(1):40-5 - PubMed
  40. Physiol Rev. 1968 Jan;48(1):252-310 - PubMed
  41. Science. 1989 Dec 22;246(4937):1620-2 - PubMed
  42. Front Endocrinol (Lausanne). 2017 Sep 28;8:254 - PubMed
  43. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5677-81 - PubMed
  44. J Endocrinol Invest. 1994 Nov;17(10):809-16 - PubMed
  45. Exp Clin Endocrinol Diabetes. 1999;107 Suppl 3:S84-7 - PubMed
  46. Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):33-52 - PubMed
  47. Clin Endocrinol (Oxf). 1995 Oct;43(4):465-71 - PubMed
  48. Front Biosci (Landmark Ed). 2020 Jan 1;25:229-241 - PubMed
  49. Endocrinol Metab Clin North Am. 2000 Jun;29(2):339-55, vii - PubMed
  50. Thyroid. 2016 Oct;26(10):1343-1421 - PubMed
  51. Endocr Rev. 1998 Dec;19(6):673-716 - PubMed
  52. Horm Metab Res. 2018 Dec;50(12):853-862 - PubMed
  53. J Thyroid Res. 2012;2012:182176 - PubMed
  54. Thyroid. 2013 Jan;23(1):14-24 - PubMed

Publication Types