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Kumral D, Cesnaite E, Beyer F, et al. Relationship between regional white matter hyperintensities and alpha oscillations in older adults. Neurobiol Aging. 2021;112:1-11doi: 10.1016/j.neurobiolaging.2021.10.006.
Kumral, D., Cesnaite, E., Beyer, F., Hofmann, S. M., Hensch, T., Sander, C., Hegerl, U., Haufe, S., Villringer, A., Witte, A. V., & Nikulin, V. V. (2021). Relationship between regional white matter hyperintensities and alpha oscillations in older adults. Neurobiology of aging, 1121-11. https://doi.org/10.1016/j.neurobiolaging.2021.10.006
Kumral, Deniz, et al. "Relationship between regional white matter hyperintensities and alpha oscillations in older adults." Neurobiology of aging vol. 112 (2021): 1-11. doi: https://doi.org/10.1016/j.neurobiolaging.2021.10.006
Kumral D, Cesnaite E, Beyer F, Hofmann SM, Hensch T, Sander C, Hegerl U, Haufe S, Villringer A, Witte AV, Nikulin VV. Relationship between regional white matter hyperintensities and alpha oscillations in older adults. Neurobiol Aging. 2021 Oct 20;112:1-11. doi: 10.1016/j.neurobiolaging.2021.10.006. Epub 2021 Oct 20. PMID: 35007997.
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Neurobiol Aging. 2021 Oct 20;112:1-11. doi: 10.1016/j.neurobiolaging.2021.10.006. Epub 2021 Oct 20.

Relationship between regional white matter hyperintensities and alpha oscillations in older adults.

Neurobiology of aging

Deniz Kumral, Elena Cesnaite, Frauke Beyer, Simon M Hofmann, Tilman Hensch, Christian Sander, Ulrich Hegerl, Stefan Haufe, Arno Villringer, A Veronica Witte, Vadim V Nikulin

Affiliations

  1. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Institute of Psychology, Neuropsychology, University of Freiburg, Freiburg im Breisgau, Germany; Clinical Psychology and Psychotherapy Unit, Institute of Psychology, University of Freiburg, Freiburg im Breisgau, Germany. Electronic address: [email protected].
  2. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  3. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; CRC Obesity Mechanisms, Subproject A1, University of Leipzig, Leipzig, Germany.
  4. Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany; LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Department of Psychology, IU International University of Applied Sciences, Erfurt, Germany.
  5. Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany; LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  6. Department of Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany.
  7. Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany; Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.
  8. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Clinic for Cognitive Neurology, University Medical Center Leipzig, Germany.
  9. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; CRC Obesity Mechanisms, Subproject A1, University of Leipzig, Leipzig, Germany; Clinic for Cognitive Neurology, University Medical Center Leipzig, Germany.
  10. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany; Centre for Cognition and Decision making, Institute for Cognitive Neuroscience, HSE University, Moscow, Russia; Neurophysics Group, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

PMID: 35007997 DOI: 10.1016/j.neurobiolaging.2021.10.006

Abstract

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7-13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N = 907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and long-range temporal correlations. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMHs affecting a spatial organization of alpha sources.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Aging; Alpha power; EEG; MRI; Resting-state; White matter hyperintensity

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