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Debus D, Genç S, Kurz P, et al. Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®). Am J Trop Med Hyg. 2022;doi: 10.4269/ajtmh.21-0962.
Debus, D., Genç, S., Kurz, P., Holzer, M., Bauer, K., Heimke-Brinck, R., Baier, M., Sebald, H., Debus, A., Bogdan, C., & Stahl, K. W. (2022). Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®). The American journal of tropical medicine and hygiene, . https://doi.org/10.4269/ajtmh.21-0962
Debus, Dirk, et al. "Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®)." The American journal of tropical medicine and hygiene vol. (2022). doi: https://doi.org/10.4269/ajtmh.21-0962
Debus D, Genç S, Kurz P, Holzer M, Bauer K, Heimke-Brinck R, Baier M, Sebald H, Debus A, Bogdan C, Stahl KW. Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®). Am J Trop Med Hyg. 2022 Jan 10; doi: 10.4269/ajtmh.21-0962. Epub 2022 Jan 10. PMID: 35008061.
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Am J Trop Med Hyg. 2022 Jan 10; doi: 10.4269/ajtmh.21-0962. Epub 2022 Jan 10.

Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®).

The American journal of tropical medicine and hygiene

Dirk Debus, Semra Genç, Philipp Kurz, Martin Holzer, Kurt Bauer, Ralph Heimke-Brinck, Martin Baier, Heidi Sebald, Andrea Debus, Christian Bogdan, Kurt-Wilhelm Stahl

Affiliations

  1. Department of Dermatology, Paracelsus Medizinische Privatuniversität, Klinikum Nürnberg, Prof.-Ernst-Nathan-Straße 1, Germany.
  2. Institute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstraße 21, Freiburg, Germany.
  3. Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universität, Hermann-Herder-Straße 9, Freiburg, Germany.
  4. Pharmacy Department, Universitätsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany.
  5. Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany.
  6. Medical Immunology Campus Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Schlossplatz 1, Erlangen, Germany.
  7. Waisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, Günterstalstraße 60, Freiburg, Germany.

PMID: 35008061 DOI: 10.4269/ajtmh.21-0962

Abstract

Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5½-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by Leishmania tropica. The patient received topical treatment with LeiProtect®, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.

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