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Cavalluzzo B, Mauriello A, Ragone C, et al. Novel Molecular Targets for Hepatocellular Carcinoma. Cancers (Basel). 2021;14(1)doi: 10.3390/cancers14010140.
Cavalluzzo, B., Mauriello, A., Ragone, C., Manolio, C., Tornesello, M. L., Buonaguro, F. M., Tvingsholm, S. A., Hadrup, S. R., Tagliamonte, M., & Buonaguro, L. (2021). Novel Molecular Targets for Hepatocellular Carcinoma. Cancers, 14(1), . https://doi.org/10.3390/cancers14010140
Cavalluzzo, Beatrice, et al. "Novel Molecular Targets for Hepatocellular Carcinoma." Cancers vol. 14,1 (2021). doi: https://doi.org/10.3390/cancers14010140
Cavalluzzo B, Mauriello A, Ragone C, Manolio C, Tornesello ML, Buonaguro FM, Tvingsholm SA, Hadrup SR, Tagliamonte M, Buonaguro L. Novel Molecular Targets for Hepatocellular Carcinoma. Cancers (Basel). 2021 Dec 28;14(1). doi: 10.3390/cancers14010140. PMID: 35008303.
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Cancers (Basel). 2021 Dec 28;14(1). doi: 10.3390/cancers14010140.

Novel Molecular Targets for Hepatocellular Carcinoma.

Cancers

Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Carmen Manolio, Maria Lina Tornesello, Franco M Buonaguro, Siri Amanda Tvingsholm, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro

Affiliations

  1. Innovative Immunological Models Unit, Istituto Nazionale Tumori-IRCCS-"Fond G. Pascale", 80131 Naples, Italy.
  2. Molecular Biology and Viral Oncogenesis Unit, Istituto Nazionale Tumori-IRCCS-"Fond G. Pascale", 80131 Naples, Italy.
  3. T-Cells and Cancer, Experimental & Translational Immunology (XTI), Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

PMID: 35008303 DOI: 10.3390/cancers14010140

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer globally. Indeed, only a few treatments are available, most of which are effective only for the early stages of the disease. Therefore, there is an urgent needing for potential markers for a specifically targeted therapy. Candidate proteins were selected from datasets of The Human Protein Atlas, in order to identify specific tumor-associated proteins overexpressed in HCC samples associated with poor prognosis. Potential epitopes were predicted from such proteins, and homology with peptides derived from viral proteins was assessed. A multiparametric validation was performed, including recognition by PBMCs from HCC-patients and healthy donors, showing a T-cell cross-reactivity with paired epitopes. These results provide novel HCC-specific tumor-associated antigens (TAAs) for immunotherapeutic anti-HCC strategies potentially able to expand pre-existing virus-specific CD8

Keywords: cancer immunotherapy; hepatocellular carcinoma; tumor-associated antigens

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Grant support