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Moreira AC, Silva T, Mesquita G, et al. H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection. Int J Mol Sci. 2021;23(1)doi: 10.3390/ijms23010269.
Moreira, A. C., Silva, T., Mesquita, G., Gomes, A. C., Bento, C. M., Neves, J. V., Rodrigues, D. F., Rodrigues, P. N., Almeida, A. A., Santambrogio, P., & Gomes, M. S. (2021). H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010269
Moreira, Ana C, et al. "H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection." International journal of molecular sciences vol. 23,1 (2021). doi: https://doi.org/10.3390/ijms23010269
Moreira AC, Silva T, Mesquita G, Gomes AC, Bento CM, Neves JV, Rodrigues DF, Rodrigues PN, Almeida AA, Santambrogio P, Gomes MS. H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection. Int J Mol Sci. 2021 Dec 27;23(1). doi: 10.3390/ijms23010269. PMID: 35008695.
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Int J Mol Sci. 2021 Dec 27;23(1). doi: 10.3390/ijms23010269.

H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection.

International journal of molecular sciences

Ana C Moreira, Tânia Silva, Gonçalo Mesquita, Ana Cordeiro Gomes, Clara M Bento, João V Neves, Daniela F Rodrigues, Pedro N Rodrigues, Agostinho A Almeida, Paolo Santambrogio, Maria Salomé Gomes

Affiliations

  1. i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
  2. IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
  3. ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
  4. Programa Doutoral em Biologia Molecular e Celular (MCbiology), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, 4200-135 Porto, Portugal.
  5. LAQV/REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
  6. Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

PMID: 35008695 DOI: 10.3390/ijms23010269

Abstract

During infections, the host redistributes iron in order to starve pathogens from this nutrient. Several proteins are involved in iron absorption, transport, and storage. Ferritin is the most important iron storage protein. It is composed of variable proportions of two peptides, the L- and H-ferritins (FTL and FTH). We previously showed that macrophages increase their expression of FTH1 when they are infected in vitro with

Keywords: H-ferritin; ferritin; ferroportin; histopathology; infection; iron tissue distribution; liver; mouse; mycobacterium

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