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Lozano-Rodríguez R, Valentín-Quiroga J, Avendaño-Ortiz J, et al. Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19. Cell Rep. 2021;38(2):110235doi: 10.1016/j.celrep.2021.110235.
Lozano-Rodríguez, R., Valentín-Quiroga, J., Avendaño-Ortiz, J., Martín-Quirós, A., Pascual-Iglesias, A., Terrón-Arcos, V., Montalbán-Hernández, K., Casalvilla-Dueñas, J. C., Bergón-Gutiérrez, M., Alcamí, J., García-Pérez, J., Cascajero, A., García-Garrido, M. �. �., Balzo-Castillo, �. �. D., Peinado, M., Gómez, L., Llorente-Fernández, I., Martín-Miguel, G., Herrero-Benito, C., Benito, J. M., Rallón, N., Vela-Olmo, C., López-Morejón, L., Cubillos-Zapata, C., Aguirre, L. A., Fresno, C. D., & López-Collazo, E. (2022). Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19. Cell reports, 38(2), 110235. https://doi.org/10.1016/j.celrep.2021.110235
Lozano-Rodríguez, Roberto, et al. "Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19." Cell reports vol. 38,2 (2022): 110235. doi: https://doi.org/10.1016/j.celrep.2021.110235
Lozano-Rodríguez R, Valentín-Quiroga J, Avendaño-Ortiz J, Martín-Quirós A, Pascual-Iglesias A, Terrón-Arcos V, Montalbán-Hernández K, Casalvilla-Dueñas JC, Bergón-Gutiérrez M, Alcamí J, García-Pérez J, Cascajero A, García-Garrido MÁ, Balzo-Castillo ÁD, Peinado M, Gómez L, Llorente-Fernández I, Martín-Miguel G, Herrero-Benito C, Benito JM, Rallón N, Vela-Olmo C, López-Morejón L, Cubillos-Zapata C, Aguirre LA, Fresno CD, López-Collazo E. Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19. Cell Rep. 2022 Jan 11;38(2):110235. doi: 10.1016/j.celrep.2021.110235. Epub 2021 Dec 21. PMID: 34986327; PMCID: PMC8687760.
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Cell Rep. 2022 Jan 11;38(2):110235. doi: 10.1016/j.celrep.2021.110235. Epub 2021 Dec 21.

Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19.

Cell reports

Roberto Lozano-Rodríguez, Jaime Valentín-Quiroga, José Avendaño-Ortiz, Alejandro Martín-Quirós, Alejandro Pascual-Iglesias, Verónica Terrón-Arcos, Karla Montalbán-Hernández, José Carlos Casalvilla-Dueñas, Marta Bergón-Gutiérrez, José Alcamí, Javier García-Pérez, Almudena Cascajero, Miguel Ángel García-Garrido, Álvaro Del Balzo-Castillo, María Peinado, Laura Gómez, Irene Llorente-Fernández, Gema Martín-Miguel, Carmen Herrero-Benito, José Miguel Benito, Norma Rallón, Carmen Vela-Olmo, Lissette López-Morejón, Carolina Cubillos-Zapata, Luis A Aguirre, Carlos Del Fresno, Eduardo López-Collazo

Affiliations

  1. The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain.
  2. Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Madrid, Spain.
  3. AIDS Immunopathogenesis Unit, National Microbiology Centre, Instituto de Salud Carlos III, Madrid, Spain.
  4. The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Madrid, Spain.
  5. Intensive Care Unit, Infanta Cristina University Hospital, Parla, Madrid, Spain.
  6. Pediatric Intensive Care Unit, 12 de Octubre University Hospital, Madrid, Spain.
  7. HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain; Hospital Universitario Rey Juan Carlos, Móstoles, Spain.
  8. Eurofins-Ingenasa, Madrid, Spain.
  9. The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain.
  10. The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain. Electronic address: [email protected].
  11. The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain. Electronic address: [email protected].

PMID: 34986327 PMCID: PMC8687760 DOI: 10.1016/j.celrep.2021.110235

Abstract

We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak after one vaccine shot in individuals recovered from COVID-19, while a second dose is needed in naive subjects, although the latter group shows reduced levels all along the analyzed period. Despite how the neutralization capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mirrors this behavior early after vaccination, both groups show comparable neutralizing antibodies and S-specific B cell levels late post-vaccination. When studying cellular responses, naive individuals exhibit higher SARS-CoV-2-specific cytokine production, CD4

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords: BNT162b2 vaccine; COVID-19-recovered; SARS-CoV-2; antigen-specific T cell; cellular responses; cytokine production; humoral responses; memory B cell; proliferation; spike

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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