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Serrano-Aroca Á, Ferrandis-Montesinos M, Wang R. Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2. ACS Appl Bio Mater. 2021;4(8):5897-5907doi: 10.1021/acsabm.1c00523.
Serrano-Aroca, �. �., Ferrandis-Montesinos, M., & Wang, R. (2021). Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2. ACS applied bio materials, 4(8), 5897-5907. https://doi.org/10.1021/acsabm.1c00523
Serrano-Aroca, Ángel, et al. "Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2." ACS applied bio materials vol. 4,8 (2021): 5897-5907. doi: https://doi.org/10.1021/acsabm.1c00523
Serrano-Aroca Á, Ferrandis-Montesinos M, Wang R. Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2. ACS Appl Bio Mater. 2021 Aug 16;4(8):5897-5907. doi: 10.1021/acsabm.1c00523. Epub 2021 Jul 13. PMID: 35006918; PMCID: PMC8291135.
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ACS Appl Bio Mater. 2021 Aug 16;4(8):5897-5907. doi: 10.1021/acsabm.1c00523. Epub 2021 Jul 13.

Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2.

ACS applied bio materials

Ángel Serrano-Aroca, María Ferrandis-Montesinos, Ruibing Wang

Affiliations

  1. Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain.
  2. Institute of Bioengineering, Universidad Miguel Hernández, Campus de Elche, 03202 Elche, Alicante, Spain.
  3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.

PMID: 35006918 PMCID: PMC8291135 DOI: 10.1021/acsabm.1c00523

Abstract

The COVID-19 pandemic has made it essential to explore alternative antiviral materials. Alginate is a biodegradable, renewable, biocompatible, water-soluble and antiviral biopolymer with many potential biomedical applications. In this regard, this review shows 17 types of viruses that have been tested in contact with alginate and its related biomaterials. Most of these studies show that alginate-based materials possess little or no toxicity and are able to inhibit a wide variety of viruses affecting different organisms: in humans by the human immunodeficiency virus type 1, the hepatitis A, B, and C viruses, Sindbis virus, herpes simplex virus type 1 and 2, poliovirus type 1, rabies virus, rubella virus, and the influenza virus; in mice by the murine norovirus; in bacteria by the T4 coliphage, and in plants by the tobacco mosaic virus and the potato virus X. Many of these are enveloped positive-sense single-stranded RNA viruses, like SARS-CoV-2, which render alginate-based materials highly promising in the COVID-19 pandemic.

Keywords: SARS-CoV-2; alginates; antiviral activities; biomaterials; viruses

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