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Molecules. 2021 Dec 30;27(1). doi: 10.3390/molecules27010225.

Preparation of Oxysterols by C-H Oxidation of Dibromocholestane with Ru(Bpga) Catalyst.

Molecules (Basel, Switzerland)

Yui Fujii, Makoto Yoritate, Kana Makino, Kazunobu Igawa, Daiki Takeda, Daiki Doiuchi, Katsuhiko Tomooka, Tatsuya Uchida, Go Hirai

Affiliations

  1. Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Fukuoka, Japan.
  2. Institute for Materials Chemistry and Engineering, Integrated Research Consortium on Chemical Sciences (IRCCS), Kyushu University, Kasuga 816-8580, Fukuoka, Japan.
  3. Department of Chemistry, Graduate School of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Fukuoka, Japan.

PMID: 35011456 PMCID: PMC8746986 DOI: 10.3390/molecules27010225

Abstract

Seven mono- and dihydroxycholesterols were prepared by direct C-H oxidation of the cholestane skeleton with a recently developed Ru(Bpga) catalyst (Ru(Bpga) = [RuCl (bpga) (PPh

Keywords: 25-hydroxycholesterol; C–H oxidation; Ru (bpga); cholesterol; dihydroxycholesterol; oxysterol

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