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Fuloria S, Yusri MAA, Sekar M, et al. Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment. Molecules. 2022;27(1)doi: 10.3390/molecules27010265.
Fuloria, S., Yusri, M. A. A., Sekar, M., Gan, S. H., Rani, N. N. I. M., Lum, P. T., Ravi, S., Subramaniyan, V., Azad, A. K., Jeyabalan, S., Wu, Y. S., Meenakshi, D. U., Sathasivam, K. V., & Fuloria, N. K. (2022). Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment. Molecules (Basel, Switzerland), 27(1), . https://doi.org/10.3390/molecules27010265
Fuloria, Shivkanya, et al. "Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment." Molecules (Basel, Switzerland) vol. 27,1 (2022). doi: https://doi.org/10.3390/molecules27010265
Fuloria S, Yusri MAA, Sekar M, Gan SH, Rani NNIM, Lum PT, Ravi S, Subramaniyan V, Azad AK, Jeyabalan S, Wu YS, Meenakshi DU, Sathasivam KV, Fuloria NK. Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment. Molecules. 2022 Jan 01;27(1). doi: 10.3390/molecules27010265. PMID: 35011497; PMCID: PMC8746870.
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Molecules. 2022 Jan 01;27(1). doi: 10.3390/molecules27010265.

Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment.

Molecules (Basel, Switzerland)

Shivkanya Fuloria, Muhamad Azrul Amir Yusri, Mahendran Sekar, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Pei Teng Lum, Subban Ravi, Vetriselvan Subramaniyan, Abul Kalam Azad, Srikanth Jeyabalan, Yuan Seng Wu, Dhanalekshmi Unnikrishnan Meenakshi, Kathiresan V Sathasivam, Neeraj Kumar Fuloria

Affiliations

  1. Faculty of Pharmacy, AIMST University, Bedong 08100, Malaysia.
  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.
  3. School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia.
  4. Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.
  5. Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore 641021, India.
  6. Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, Jenjarom Selangor, Shah Alam 42610, Malaysia.
  7. Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai 600116, India.
  8. Centre for Virus and Vaccine Research, School of Medical and Life Sciences, Sunway University, Subang Jaya 47500, Malaysia.
  9. Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya 47500, Malaysia.
  10. College of Pharmacy, National University of Science and Technology, Muscat 130, Oman.
  11. Faculty of Applied Sciences, AIMST University, Bedong 08100, Malaysia.

PMID: 35011497 PMCID: PMC8746870 DOI: 10.3390/molecules27010265

Abstract

Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI) in animals. Scopus, PubMed, and Web of Science databases were used to find the relevant articles and discuss the effects of genistein in the brain, including its pharmacokinetics, bioavailability, behavioral effects, and some of the potential mechanisms of action on memory in several animal models. The results of the preclinical studies highly suggested that genistein is highly effective in enhancing the cognitive performance of the MI animal models, specifically in the memory domain, including spatial, recognition, retention, and reference memories, through its ability to reduce oxidative stress and attenuate neuroinflammation. This review also highlighted challenges and opportunities to improve the drug delivery of genistein for treating MI. Along with that, the possible structural modifications and derivatives of genistein to improve its physicochemical and drug-likeness properties are also discussed. The outcomes of the review proved that genistein can enhance the cognitive performance and ameliorate MI in different preclinical studies, thus indicating its potential as a natural lead for the design and development of a novel neuroprotective drug.

Keywords: genistein; isoflavone; memory impairment; neuroprotection; phytomedicine

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