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Agwuegbo UT, Colley E, Albert AP, et al. Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling. Front Endocrinol (Lausanne). 2021;12:765727doi: 10.3389/fendo.2021.765727.
Agwuegbo, U. T., Colley, E., Albert, A. P., Butnev, V. Y., Bousfield, G. R., & Jonas, K. C. (2021). Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling. Frontiers in endocrinology, 12765727. https://doi.org/10.3389/fendo.2021.765727
Agwuegbo, Uchechukwu T, et al. "Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling." Frontiers in endocrinology vol. 12 (2021): 765727. doi: https://doi.org/10.3389/fendo.2021.765727
Agwuegbo UT, Colley E, Albert AP, Butnev VY, Bousfield GR, Jonas KC. Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling. Front Endocrinol (Lausanne). 2021 Dec 03;12:765727. doi: 10.3389/fendo.2021.765727. eCollection 2021. PMID: 34925235; PMCID: PMC8678890.
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Front Endocrinol (Lausanne). 2021 Dec 03;12:765727. doi: 10.3389/fendo.2021.765727. eCollection 2021.

Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling.

Frontiers in endocrinology

Uchechukwu T Agwuegbo, Emily Colley, Anthony P Albert, Viktor Y Butnev, George R Bousfield, Kim C Jonas

Affiliations

  1. School of Life Course and Population Sciences, Department of Women and Children's Health, Guy's Campus, King's College London, London, United Kingdom.
  2. Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom.
  3. Vascular Biology Research Centre, Molecular & Clinical Science Research Centre, St George's University of London, London, United Kingdom.
  4. Department of Biological Sciences, Wichita State University, Wichita, KS, United States.

PMID: 34925235 PMCID: PMC8678890 DOI: 10.3389/fendo.2021.765727

Abstract

Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive

Copyright © 2021 Agwuegbo, Colley, Albert, Butnev, Bousfield and Jonas.

Keywords: G protein-coupled receptors (GPCR); follicle-stimulating hormone; follicle-stimulating hormone receptor; gonadotropic hormones; oligomerization; oligomers

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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