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Bercea M. Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels. Polymers (Basel). 2021;14(1)doi: 10.3390/polym14010130.
Bercea, M. (2021). Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels. Polymers, 14(1), . https://doi.org/10.3390/polym14010130
Bercea, Maria. "Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels." Polymers vol. 14,1 (2021). doi: https://doi.org/10.3390/polym14010130
Bercea M. Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels. Polymers (Basel). 2021 Dec 30;14(1). doi: 10.3390/polym14010130. PMID: 35012155; PMCID: PMC8747654.
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Polymers (Basel). 2021 Dec 30;14(1). doi: 10.3390/polym14010130.

Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels.

Polymers

Maria Bercea

Affiliations

  1. "Petru Poni" Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

PMID: 35012155 PMCID: PMC8747654 DOI: 10.3390/polym14010130

Abstract

The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA unfolding. By applying three successive freezing/thawing cycles, a stable porous network structure with elastic properties is designed, as evidenced by SEM and rheology. The hydrogels exhibit self-healing properties when the samples are cut into two pieces; the intermolecular interactions are reestablished in time and therefore the fragments repair themselves. The effects of the BSA content, loaded deformation and temperature on the self-healing ability of hydrogels are presented and discussed through rheological data. Due to their versatile viscoelastic behavior, the properties of PVA/HPC/BSA hydrogels can be tuned during their preparation in order to achieve suitable biomaterials for targeted applications.

Keywords: BSA; HPC; PVA; hybrid network; self-healing; viscoelasticity

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