Display options
Cite
Garg S, Kumar Singh V, Chandra Sonkar S, et al. Pattern of serum protein capillary electrophoretogram in SARS- CoV-2 infection. Clin Chim Acta. 2022;doi: 10.1016/j.cca.2022.01.003.
Garg, S., Kumar Singh, V., Chandra Sonkar, S., Kelkar, H., Singh, S., Garg, S., Arya, M., Husain, F., Chandra, L., Chitkara, A., Talukdar, T., Goswami, B., & Chandra Koner, B. (2022). Pattern of serum protein capillary electrophoretogram in SARS- CoV-2 infection. Clinica chimica acta; international journal of clinical chemistry, . https://doi.org/10.1016/j.cca.2022.01.003
Garg, Surbhi, et al. "Pattern of serum protein capillary electrophoretogram in SARS- CoV-2 infection." Clinica chimica acta; international journal of clinical chemistry vol. (2022). doi: https://doi.org/10.1016/j.cca.2022.01.003
Garg S, Kumar Singh V, Chandra Sonkar S, Kelkar H, Singh S, Garg S, Arya M, Husain F, Chandra L, Chitkara A, Talukdar T, Goswami B, Chandra Koner B. Pattern of serum protein capillary electrophoretogram in SARS- CoV-2 infection. Clin Chim Acta. 2022 Jan 07; doi: 10.1016/j.cca.2022.01.003. Epub 2022 Jan 07. PMID: 35007527; PMCID: PMC8739368.
Copy Download .nbib Format: NLM
Share it on

Clin Chim Acta. 2022 Jan 07; doi: 10.1016/j.cca.2022.01.003. Epub 2022 Jan 07.

Pattern of serum protein capillary electrophoretogram in SARS- CoV-2 infection.

Clinica chimica acta; international journal of clinical chemistry

Surbhi Garg, Vijay Kumar Singh, Subash Chandra Sonkar, Harshit Kelkar, Shlesh Singh, Sandeep Garg, Mona Arya, Farah Husain, Lal Chandra, Anubhuti Chitkara, Tanmaya Talukdar, Binita Goswami, Bidhan Chandra Koner

Affiliations

  1. Department of Biochemistry, Maulana Azad Medical College (MAMC) & L.N. Hospital, New Delhi, India PIN110 002.
  2. Multidisciplinary Research Unit (MRU), Maulana Azad Medical College, New Delhi, India, PIN 110002.
  3. Department of Medicine, Maulana Azad Medical College & L.N. Hospital, New Delhi, India PIN 110002.
  4. Department of Anesthesia, Maulana Azad Medical College & L.N. Hospital, New Delhi, India PIN 110002.
  5. Department of TB and Chest Diseases, Lady Hardinge Medical College, New Delhi,PIN-110001.
  6. Department of Biochemistry, Maulana Azad Medical College (MAMC) & L.N. Hospital, New Delhi, India PIN110 002; Multidisciplinary Research Unit (MRU), Maulana Azad Medical College, New Delhi, India, PIN 110002.
  7. Department of Biochemistry, Maulana Azad Medical College (MAMC) & L.N. Hospital, New Delhi, India PIN110 002; Multidisciplinary Research Unit (MRU), Maulana Azad Medical College, New Delhi, India, PIN 110002. Electronic address: [email protected].

PMID: 35007527 PMCID: PMC8739368 DOI: 10.1016/j.cca.2022.01.003

Abstract

BACKGROUND AND AIMS: Monoclonal/biclonalgammopathy of unknown significance (MGUS/BGUS) is observed in COVID-19. This study was conducted to determine the changes in serum protein electrophoresis (SPEP) in COVID-19.

MATERIALS AND METHODS: In this descriptive (cross-sectional) study, serum inflammatory markers (CRP, IL-6 and ferritin) were measured and SPEP was carried out by capillary electrophoresis method in 35 controls and 30 moderate & 58 severe COVID-19 cases.

RESULTS: Serum inflammatory markers were increased in COVID-19 cases with severity. M-band(s), β-γ bridging and pre-albumin band(s) on SPEP were observed in 15.5, 11 & 12% of severe cases and 3, 4 & 0% moderate COVID-19 cases respectively. Area under curve (AUC) of α 1 and α 2 bands of SPEP increased significantly in severe COVID-19.

CONCLUSIONS: We conclude that SPEP changes like the appearance of M-band(s) indicating MGUS(BGUS), β- γ bridging indicating the presence of fast-moving immunoglobulins, pre-albumin band indicating the rise in serum transthyretin level and the increase in AUC of α 1 and α 2 bands indicating the rise in positive acute phase reactants occur in COVID-19. The occurrence and magnitude of these changes are higher in severe COVID-19 than that in moderate COVID-19. The diagnostic and prognostic significance of these SPEP changes are worth exploring.

Copyright © 2022. Published by Elsevier B.V.

Keywords: COVID-19; Capillary electrophoresis; Monoclonal gammopathy; Pre-albumin; SARS-CoV-2

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

References

  1. Am J Clin Pathol. 1994 Apr;101(4):475-7 - PubMed
  2. Blood Cells Mol Dis. 2020 Nov;85:102481 - PubMed
  3. Microbes Infect. 2021 May-Jun;23(4-5):104808 - PubMed
  4. Clin Chim Acta. 2020 Dec;511:342-345 - PubMed
  5. Biochem Res Int. 2017;2017:9196538 - PubMed
  6. Int J Obes (Lond). 2020 Aug;44(8):1790-1792 - PubMed
  7. FEBS J. 2010 Oct;277(19):4066-75 - PubMed
  8. J Environ Public Health. 2021 Apr 22;2021:6631721 - PubMed
  9. Infect Dis Rep. 2021 Apr 01;13(2):259-284 - PubMed
  10. Sci Adv. 2020 Dec 9;6(50): - PubMed
  11. N Engl J Med. 2006 Mar 30;354(13):1362-9 - PubMed
  12. Front Pediatr. 2021 Mar 30;8:607647 - PubMed
  13. IDCases. 2020;22:e00975 - PubMed
  14. Br J Haematol. 2020 Aug;190(3):e130-e133 - PubMed
  15. Int J Surg. 2020 Apr;76:71-76 - PubMed
  16. Hematol Transfus Cell Ther. 2020 Jul - Sep;42(3):218-220 - PubMed
  17. J Mol Neurosci. 2012 Sep;48(1):1-13 - PubMed
  18. Nutrition. 2020 Oct;78:110930 - PubMed
  19. J Thromb Thrombolysis. 2021 Oct;52(3):772-778 - PubMed
  20. Cureus. 2020 May 1;12(5):e7918 - PubMed
  21. Bratisl Lek Listy. 2020;121(9):628-633 - PubMed
  22. Vet Pathol. 2010 Nov;47(6):1064-70 - PubMed

Publication Types