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Bhowal P, Karmakar PB, Dey D, et al. Aminoacyl-tRNA synthetases, the indispensable players in Lung tumorigenesis. Protein Pept Lett. 2022;doi: 10.2174/0929866529666220110143520.
Bhowal, P., Karmakar, P. B., Dey, D., Manna, R., Roy, D., & Banerjee, R. (2022). Aminoacyl-tRNA synthetases, the indispensable players in Lung tumorigenesis. Protein and peptide letters, . https://doi.org/10.2174/0929866529666220110143520
Bhowal, Pratyasha, et al. "Aminoacyl-tRNA synthetases, the indispensable players in Lung tumorigenesis." Protein and peptide letters vol. (2022). doi: https://doi.org/10.2174/0929866529666220110143520
Bhowal P, Karmakar PB, Dey D, Manna R, Roy D, Banerjee R. Aminoacyl-tRNA synthetases, the indispensable players in Lung tumorigenesis. Protein Pept Lett. 2022 Jan 10; doi: 10.2174/0929866529666220110143520. Epub 2022 Jan 10. PMID: 35016593.
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Protein Pept Lett. 2022 Jan 10; doi: 10.2174/0929866529666220110143520. Epub 2022 Jan 10.

Aminoacyl-tRNA synthetases, the indispensable players in Lung tumorigenesis.

Protein and peptide letters

Pratyasha Bhowal, Priyanka Biswas Karmakar, Debkanya Dey, Riya Manna, Debraj Roy, Rajat Banerjee

Affiliations

  1. Department of Biotechnology and Dr. B. C Guha Centre for Genetic Engineering and Biotechnology, Faculty of Science, University of Calcutta, India.

PMID: 35016593 DOI: 10.2174/0929866529666220110143520

Abstract

Being an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered alteredexpressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs), forming a multi-tRNA synthetase complex (MSC) and divulging into theirroles outside the range of protein synthesis. In this review, we have directed our focus into the rudimentary structure of this compact associationand alsohow these aaRSs and AIMPs are involved in the maintenance and progression of lung cancer,the principal cause of most cancer-related deaths. There is substantial validation that suggests the crucial role of these prime housekeeping proteins in lung cancer regulation. Here, we have addressed the biological role that the three AIMPs and the aaRSs play in tumorigenesis, along with an outline of the different molecular mechanisms involved in the same. In conclusion, we have introduced the potentiality of these components as possible therapeutics for the evolution of new-age treatments of lung tumorigenesis.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Keywords: AIMPs; Aminoacyl-tRNA synthetases (aaRSs); MSC; inhibitors; lung cancer; signal pathways

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