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Picchioni D, Özbay PS, Mandelkow H, et al. Autonomic arousals contribute to brain fluid pulsations during sleep. Neuroimage. 2022;118888doi: 10.1016/j.neuroimage.2022.118888.
Picchioni, D., Özbay, P. S., Mandelkow, H., de Zwart, J. A., Wang, Y., van Gelderen, P., & Duyn, J. H. (2022). Autonomic arousals contribute to brain fluid pulsations during sleep. NeuroImage, 118888. https://doi.org/10.1016/j.neuroimage.2022.118888
Picchioni, Dante, et al. "Autonomic arousals contribute to brain fluid pulsations during sleep." NeuroImage vol. (2022): 118888. doi: https://doi.org/10.1016/j.neuroimage.2022.118888
Picchioni D, Özbay PS, Mandelkow H, de Zwart JA, Wang Y, van Gelderen P, Duyn JH. Autonomic arousals contribute to brain fluid pulsations during sleep. Neuroimage. 2022 Jan 08;118888. doi: 10.1016/j.neuroimage.2022.118888. Epub 2022 Jan 08. PMID: 35017126.
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Neuroimage. 2022 Jan 08;118888. doi: 10.1016/j.neuroimage.2022.118888. Epub 2022 Jan 08.

Autonomic arousals contribute to brain fluid pulsations during sleep.

NeuroImage

Dante Picchioni, Pinar S Özbay, Hendrik Mandelkow, Jacco A de Zwart, Yicun Wang, Peter van Gelderen, Jeff H Duyn

Affiliations

  1. Advance MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, Maryland.
  2. Advance MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, Maryland. Electronic address: [email protected].

PMID: 35017126 DOI: 10.1016/j.neuroimage.2022.118888

Abstract

During sleep, slow waves of neuro-electrical activity engulf the human brain and aid in the consolidation of memories. Recent research suggests that these slow waves may also promote brain health by facilitating the removal of metabolic waste, possibly by orchestrating the pulsatile flow of cerebro-spinal fluid (CSF) through local neural control over vascular tone. To investigate the role of slow waves in the generation of CSF pulsations, we analyzed functional MRI data obtained across the full sleep-wake cycle and during a respiratory task during wakefulness. This revealed a novel generating mechanism that relies on the autonomic regulation of cerebral vascular tone without requiring slow electrocortical activity or even sleep. Therefore, the role of CSF pulsations in brain waste clearance may, in part, depend on proper autoregulatory control of cerebral blood flow.

Copyright © 2022. Published by Elsevier Inc.

Conflict of interest statement

Declaration of Competing Interest Authors declare that they have no competing interests.

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