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ACS Biomater Sci Eng. 2022 Jan 12; doi: 10.1021/acsbiomaterials.1c01259. Epub 2022 Jan 12.

Biodegradable Fiducial Markers for Bimodal Near-Infrared Fluorescence- and X-ray-Based Imaging.

ACS biomaterials science & engineering

Żaneta Górecka, Dariusz Grzelecki, Wiktor Paskal, Emilia Choińska, Joanna Gilewicz, Robert Wrzesień, Wojciech Macherzyński, Michał Tracz, Elżbieta Budzińska-Wrzesień, Maria Bedyńska, Michał Kopka, Agnieszka Jackowska-Tracz, Ewelina Świątek-Najwer, Paweł K Włodarski, Janusz Jaworowski, Wojciech Święszkowski

Affiliations

  1. Division of Materials Design, Faculty of Materials Science and Engineering, Warsaw University of Technology, 141 Woloska Str., 02-507 Warsaw, Poland.
  2. Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, 02-822 Warsaw, Poland.
  3. Department of Applied Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.
  4. Department of Orthopedics and Rheumoorthopedics, Professor Adam Gruca Teaching Hospital, Centre of Postgraduate Medical Education, 05-400 Otwock, Poland.
  5. Centre for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 02-091 Warsaw, Poland.
  6. Central Laboratory of Experimental Animal, Medical University of Warsaw, 02-097 Warsaw, Poland.
  7. Faculty of Microsystem Electronics and Photonics, Wroclaw University of Science and Technology, 50-372 Wroclaw, Poland.
  8. Institute of Veterinary Medicine, Department of Food Hygiene and Public Health Protection, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.
  9. Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland.
  10. Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, 50-371 Wroclaw, Poland.

PMID: 35020357 DOI: 10.1021/acsbiomaterials.1c01259

Abstract

This study aimed to evaluate, for the first time, implantable, biodegradable fiducial markers (FMs), which were designed for bimodal, near-infrared fluorescence-based (NIRF) and X-ray-based imaging. The developed FMs had poly(l-lactide-

Keywords: X-ray medical imaging; composite bimodal fiducial markers; degradation and stability of polymeric composites; near-infrared fluorescence imaging

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