J Pharm Bioallied Sci. 2021 Nov;13:S989-S992. doi: 10.4103/jpbs.jpbs_380_21. Epub 2021 Nov 10.
Assessment of Serum Selenium and Ceruloplasmin in Potentially Malignant Disorders and Oral Cancer.
Journal of pharmacy & bioallied sciences
Mathew O Mampilly, Nidhi Ravindran, Mohamed Shajith Parambil, Kumar Nilesh, Parvathi Jayagopalan, Debjit Dhamali
Affiliations
Affiliations
- Department of Oral and Maxillofacial Surgery and Dentistry, ESIC Medical College and PG Institute, Bengaluru, Karnataka, India.
- Department of Dentistry, Sree Narayana Institute of Medical Sciences, Kochi, Kerala, India.
- Department of Oral and Maxillofacial Surgery and Dentistry, King Faisal Hospital, Makkah Al Mukarramah, KSA.
- Department of Oral and Maxillofacial Surgery, School of Dental Science, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.
- Department of Oral and Maxillofacial Surgery, Royal Dental College, Palakkad, Kerala, India.
- Department of Dentistry, IqCity Medical College and Hospital, Durgapur, West Bengal, India.
PMID: 35017913
PMCID: PMC8686891 DOI: 10.4103/jpbs.jpbs_380_21
Abstract
INTRODUCTION: Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern. Diet and immunity have been identified as important modifiable factors in such diseases.
MATERIALS AND METHODS: A total of 20 patients and 10 healthy individuals, aged 30-60 years, were chosen from the outpatient Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, Karnataka. The participants were grouped into three: Group 1: (10 healthy individuals), Group 2: (10 oral leukoplakia patients) and Group 3: (10 squamous cell carcinoma patients). Blood was chosen as the investigative medium. Ceruloplasmin was estimated by the diamine oxidase method. The technique of atomic absorption developed by Sir Alan Walsh in 1950 has become the preferred method of elemental analysis of selenium (atomic absorption spectrometer). Statistical analysis of the data obtained was done using one-way ANOVA test and the Turkey multiple comparisons test.
RESULTS: The intergroup comparison of ceruloplasmin shows that the mean value of Group I (Control) was 31.746 mg/dl, the mean value of Group II (leukoplakia) was 81.411 mg/dl, and the mean value of Group III (squamous cell carcinoma) was 90.7120 mg/dl. The intergroup comparison of selenium levels shows that the mean value of Group I (Control) was 119.937 (ng/ml), the mean value of Group II (leukoplakia) was 109.17 (ng/ml), and the mean value of Group III (squamous cell carcinoma) was 99.6230 (ng/ml).
CONCLUSION: Antioxidants are an important defense system against free radical damage to cells. Ceruloplasmin and selenium levels in serum could be used as disease markers in leukoplakia and squamous cell carcinoma.
Copyright: © 2021 Journal of Pharmacy and Bioallied Sciences.
Keywords: Antigen-antibody complex; ceruloplasmin; mouth Neoplasm's; selenium
Conflict of interest statement
There are no conflicts of interest.
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