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Chandrasiri I, Abebe DG, Loku Yaddehige M, et al. Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications. ACS Appl Bio Mater. 2020;3(9):5664-5677doi: 10.1021/acsabm.0c00432.
Chandrasiri, I., Abebe, D. G., Loku Yaddehige, M., Williams, J. S. D., Zia, M. F., Dorris, A., Barker, A., Simms, B. L., Parker, A., Vinjamuri, B. P., Le, N., Gayton, J. N., Chougule, M. B., Hammer, N. I., Flynt, A., Delcamp, J. H., & Watkins, D. L. (2020). Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications. ACS applied bio materials, 3(9), 5664-5677. https://doi.org/10.1021/acsabm.0c00432
Chandrasiri, Indika, et al. "Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications." ACS applied bio materials vol. 3,9 (2020): 5664-5677. doi: https://doi.org/10.1021/acsabm.0c00432
Chandrasiri I, Abebe DG, Loku Yaddehige M, Williams JSD, Zia MF, Dorris A, Barker A, Simms BL, Parker A, Vinjamuri BP, Le N, Gayton JN, Chougule MB, Hammer NI, Flynt A, Delcamp JH, Watkins DL. Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications. ACS Appl Bio Mater. 2020 Sep 21;3(9):5664-5677. doi: 10.1021/acsabm.0c00432. Epub 2020 Aug 10. PMID: 35021798.
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ACS Appl Bio Mater. 2020 Sep 21;3(9):5664-5677. doi: 10.1021/acsabm.0c00432. Epub 2020 Aug 10.

Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications.

ACS applied bio materials

Indika Chandrasiri, Daniel G Abebe, Mahesh Loku Yaddehige, Jon Steven Dal Williams, Mohammad Farid Zia, Austin Dorris, Abigail Barker, Briana L Simms, Azaziah Parker, Bhavani Prasad Vinjamuri, Ngoc Le, Jacqueline N Gayton, Mahavir Bhupal Chougule, Nathan I Hammer, Alex Flynt, Jared H Delcamp, Davita L Watkins

Affiliations

  1. Department of Chemistry and Biochemistry, The University of Mississippi, University, Mississippi 38677, United States.
  2. Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.
  3. Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.

PMID: 35021798 DOI: 10.1021/acsabm.0c00432

Abstract

This study represents a successful approach toward employing polycaprolactone-polyamidoamine (PCL-PAMAM) linear dendritic block copolymer (LDBC) nanoparticles as small-molecule carriers in NIR imaging and photothermal therapy. A feasible and robust synthetic strategy was used to synthesize a library of amphiphilic LDBCs with well-controlled hydrophobic-to-hydrophilic weight ratios. Systems with a hydrophobic weight ratio higher than 70% formed nanoparticles in aqueous media, which show hydrodynamic diameters of 51.6 and 96.4 nm. These nanoparticles exhibited loading efficiencies up to 21% for a hydrophobic molecule and 64% for a hydrophilic molecule. Furthermore, successful cellular uptake was observed via trafficking into endosomal and lysosomal compartments with an encapsulated NIR theranostic agent (C3) without inducing cell death. A preliminary photothermal assessment resulted in cell death after treating the cells with encapsulated C3 and exposing them to NIR light. The results of this work confirm the potential of these polymeric materials as promising candidates in theranostic nanomedicine.

Keywords: NIR imaging; block copolymers; nanoaggregates; nanocarriers; nanoparticles; photothermal therapy; self-assembly; theranostics

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