Bull Exp Biol Med. 2022 Jan;172(3):328-331. doi: 10.1007/s10517-022-05386-6. Epub 2022 Jan 10.

A Protective Role of Okadaic Acid in Liver Injury Induced by Amoxicillin.

Bulletin of experimental biology and medicine

D Li, W Shi, X Lu, Z Liu, S Zhang, Y Sun, W Shi, X Zhu

PMID: 35006487 DOI: 10.1007/s10517-022-05386-6

Abstract

This study was performed to investigate whether okadaic acid (200 ng/kg) produces a protective effect in experimental liver injury induced by intragastric administration of 1000, 2000, and 4000 mg/kg amoxicillin in Sprague-Dawley rats (n=50). The control group was given carboxymethylcellulose sodium solution. Liver injury was assessed by the relative organ weight index, serum ALT activity, and liver malondialdehyde content. Histopathological examination of the liver from rats treated with amoxicillin revealed cell swelling, congestion, apoptosis, and necrosis. The relative liver weight index, ALT activity, and liver malondialdehyde content in these animals were higher than in the control. Administration of okadaic acid reduced the degree of amoxicillin-induced damage to hepatocytes. Thus, okadaic acid can alleviate liver injury caused by amoxicillin.

© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Keywords: ALT; amoxicillin; liver injury; okadaic acid; relative organ weight index

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