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Jurcau A, Simion A. Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies. Int J Mol Sci. 2021;23(1)doi: 10.3390/ijms23010014.
Jurcau, A., & Simion, A. (2021). Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010014
Jurcau, Anamaria, and Simion, Aurel. "Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies." International journal of molecular sciences vol. 23,1 (2021). doi: https://doi.org/10.3390/ijms23010014
Jurcau A, Simion A. Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies. Int J Mol Sci. 2021 Dec 21;23(1). doi: 10.3390/ijms23010014. PMID: 35008440; PMCID: PMC8744548.
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Int J Mol Sci. 2021 Dec 21;23(1). doi: 10.3390/ijms23010014.

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies.

International journal of molecular sciences

Anamaria Jurcau, Aurel Simion

Affiliations

  1. Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
  2. Neurology Ward, Clinical Municipal Hospital "dr. G. Curteanu" Oradea, 410154 Oradea, Romania.
  3. Neurorehabilitation Ward, Clinical Municipal Hospital "dr. G. Curteanu" Oradea, 410154 Oradea, Romania.

PMID: 35008440 PMCID: PMC8744548 DOI: 10.3390/ijms23010014

Abstract

Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which neuroinflammation is significantly involved. Research has shown that in the acute phase, neuroinflammatory cascades lead to apoptosis, disruption of the blood-brain barrier, cerebral edema, and hemorrhagic transformation, while in later stages, these pathways support tissue repair and functional recovery. The present review discusses the various cell types and the mechanisms through which neuroinflammation contributes to parenchymal injury and tissue repair, as well as therapeutic attempts made in vitro, in animal experiments, and in clinical trials which target neuroinflammation, highlighting future therapeutic perspectives.

Keywords: astrocytes; chemokines; cytokines; ischemic stroke; microglia; neuroinflammation; stem cells

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