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Ferentinos P, Tsakirides C, Swainson M, et al. The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease. Eur J Appl Physiol. 2022;doi: 10.1007/s00421-021-04876-1.
Ferentinos, P., Tsakirides, C., Swainson, M., Davison, A., Martyn-St James, M., & Ispoglou, T. (2022). The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease. European journal of applied physiology, . https://doi.org/10.1007/s00421-021-04876-1
Ferentinos, Panagiotis, et al. "The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease." European journal of applied physiology vol. (2022). doi: https://doi.org/10.1007/s00421-021-04876-1
Ferentinos P, Tsakirides C, Swainson M, Davison A, Martyn-St James M, Ispoglou T. The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease. Eur J Appl Physiol. 2022 Jan 12; doi: 10.1007/s00421-021-04876-1. Epub 2022 Jan 12. PMID: 35022875.
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Eur J Appl Physiol. 2022 Jan 12; doi: 10.1007/s00421-021-04876-1. Epub 2022 Jan 12.

The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease.

European journal of applied physiology

Panagiotis Ferentinos, Costas Tsakirides, Michelle Swainson, Adam Davison, Marrissa Martyn-St James, Theocharis Ispoglou

Affiliations

  1. Carnegie School of Sport, Leeds Beckett University, Leeds, UK.
  2. Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
  3. Flow Cytometry Facility, Leeds Institute of Cancer and Pathology St James's University Hospital, University of Leeds, Leeds, UK.
  4. Cytec Biosciences B.V, Amsterdam, The Netherlands.
  5. School of Health and Related Research, University of Sheffield, Sheffield, UK.
  6. Carnegie School of Sport, Leeds Beckett University, Leeds, UK. [email protected].

PMID: 35022875 DOI: 10.1007/s00421-021-04876-1

Abstract

Circulating endothelial progenitor cells (EPCs) contribute to vascular repair and their monitoring could have prognostic clinical value. Exercise is often prescribed for the management of cardiometabolic diseases, however, it is not fully understood how it regulates EPCs.

OBJECTIVES: to systematically examine the acute and chronic effects of different exercise modalities on circulating EPCs in patients with cardiovascular and metabolic disease.

METHODS: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed.

RESULTS: six electronic databases and reference lists of eligible studies were searched to April 2021. Thirty-six trials met the inclusion criteria including 1731 participants. Acute trials: in chronic heart failure (CHF), EPC mobilisation was acutely increased after high intensity interval or moderate intensity continuous exercise training, while findings were inconclusive after a cardiopulmonary cycling exercise test. Maximal exercise tests acutely increased EPCs in ischaemic or revascularized coronary artery disease (CAD) patients. In peripheral arterial disease (PAD), EPC levels increased up to 24 h post-exercise. In patients with compromised metabolic health, EPC mobilisation was blunted after a single exercise session. Chronic trials: in CHF and acute coronary syndrome, moderate intensity continuous protocols, with or without resistance exercise or calisthenics, increased EPCs irrespective of EPC identification phenotype. Findings were equivocal in CAD regardless of exercise mode, while in severe PAD disease EPCs increased. High intensity interval training increased EPCs in hypertensive metabolic syndrome and heart failure reduced ejection fraction.

CONCLUSION: the clinical condition and exercise modality influence the degree of EPC mobilisation and magnitude of EPC increases in the long term.

© 2022. Crown.

Keywords: Aerobic training; Cardiometabolic health; Cardiovascular disease; EPC mobilisation; Endothelial progenitor cells; Exercise; Flow cytometry; High intensity interval training; Moderate intensity continuous training; Resistance exercise; Vascular health

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