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Kostyuk SV, Proskurnina EV, Konkova MS, et al. Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells. Int J Mol Sci. 2021;23(1)doi: 10.3390/ijms23010261.
Kostyuk, S. V., Proskurnina, E. V., Konkova, M. S., Abramova, M. S., Kalianov, A. A., Ershova, E. S., Izhevskaya, V. L., Kutsev, S. I., & Veiko, N. N. (2021). Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010261
Kostyuk, Svetlana V, et al. "Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells." International journal of molecular sciences vol. 23,1 (2021). doi: https://doi.org/10.3390/ijms23010261
Kostyuk SV, Proskurnina EV, Konkova MS, Abramova MS, Kalianov AA, Ershova ES, Izhevskaya VL, Kutsev SI, Veiko NN. Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells. Int J Mol Sci. 2021 Dec 27;23(1). doi: 10.3390/ijms23010261. PMID: 35008689; PMCID: PMC8745621.
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Int J Mol Sci. 2021 Dec 27;23(1). doi: 10.3390/ijms23010261.

Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells.

International journal of molecular sciences

Svetlana V Kostyuk, Elena V Proskurnina, Marina S Konkova, Margarita S Abramova, Andrey A Kalianov, Elizaveta S Ershova, Vera L Izhevskaya, Sergey I Kutsev, Natalia N Veiko

Affiliations

  1. Laboratory of Molecular Biology, Research Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, Russia.

PMID: 35008689 PMCID: PMC8745621 DOI: 10.3390/ijms23010261

Abstract

The concept of hormesis describes a phenomenon of adaptive response to low-dose ionizing radiation (LDIR). Similarly, the concept of mitohormesis states that the adaptive program in mitochondria is activated in response to minor stress effects. The mechanisms of hormesis effects are not clear, but it is assumed that they can be mediated by reactive oxygen species. Here, we studied effects of LDIR on mitochondria in mesenchymal stem cells. We have found that X-ray radiation at a dose of 10 cGy as well as oxidized fragments of cell-free DNA (cfDNA) at a concentration of 50 ng/mL resulted in an increased expression of a large number of genes regulating the function of the mitochondrial respiratory chain complexes in human mesenchymal stem cells (MSC). Several genes remained upregulated within hours after the exposure. Both X-ray radiation and oxidized cfDNA resulted in upregulation of

Keywords: cell-free DNA; human mesenchymal stem cells; low-dose ionizing radiation; mitochondria; mitohormesis

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