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Evseeva MN, Balashova MS, Kulebyakin KY, et al. Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors. Int J Mol Sci. 2021;23(1)doi: 10.3390/ijms23010322.
Evseeva, M. N., Balashova, M. S., Kulebyakin, K. Y., & Rubtsov, Y. P. (2021). Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010322
Evseeva, Maria N, et al. "Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors." International journal of molecular sciences vol. 23,1 (2021). doi: https://doi.org/10.3390/ijms23010322
Evseeva MN, Balashova MS, Kulebyakin KY, Rubtsov YP. Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors. Int J Mol Sci. 2021 Dec 28;23(1). doi: 10.3390/ijms23010322. PMID: 35008748; PMCID: PMC8745732.
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Int J Mol Sci. 2021 Dec 28;23(1). doi: 10.3390/ijms23010322.

Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors.

International journal of molecular sciences

Maria N Evseeva, Maria S Balashova, Konstantin Y Kulebyakin, Yury P Rubtsov

Affiliations

  1. Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia.
  2. Laboratory of Bioinformatics Approaches in Combinatorial Chemistry and Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
  3. Department of Medical Genetics, Sechenov 1st State Medical University, 119991 Moscow, Russia.
  4. Laboratory of Molecular Endocrinology, Institute for Regenerative Medicine, Medical Research and Education Centre, Lomonosov Moscow State University, 119991 Moscow, Russia.
  5. Laboratory of Molecular Virology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.

PMID: 35008748 PMCID: PMC8745732 DOI: 10.3390/ijms23010322

Abstract

Obesity and type 2 diabetes are both significant contributors to the contemporary pandemic of non-communicable diseases. Both disorders are interconnected and associated with the disruption of normal homeostasis in adipose tissue. Consequently, exploring adipose tissue differentiation and homeostasis is important for the treatment and prevention of metabolic disorders. The aim of this work is to review the consecutive steps in the postnatal development of adipocytes, with a special emphasis on in vivo studies. We gave particular attention to well-known transcription factors that had been thoroughly described in vitro, and showed that the in vivo research of adipogenic differentiation can lead to surprising findings.

Keywords: CEBP/α; CEBP/β; CEBP/δ; CREB; PPARγ; adipogenesis; knockout; obesity; transcription factor

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