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Int J Mol Sci. 2021 Dec 31;23(1). doi: 10.3390/ijms23010448.

TGF-β.

International journal of molecular sciences

Keisuke Ito, Tomoya Fujie, Masahiro Shimomura, Tsuyoshi Nakano, Chika Yamamoto, Toshiyuki Kaji

Affiliations

  1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Japan.
  2. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi 274-8510, Japan.

PMID: 35008873 PMCID: PMC8745387 DOI: 10.3390/ijms23010448

Abstract

Vascular endothelial cells cover the luminal surface of blood vessels in a monolayer and play a role in the regulation of vascular functions, such as the blood coagulation-fibrinolytic system. When the monolayer is severely or repeatedly injured, platelets aggregate at the damaged site and release transforming growth factor (TGF)-β

Keywords: Smad2/3; Zrt- and Irt-like protein transporter; cadmium; endothelial cell; p38 MAPK; transforming growth factor-β1

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