Display options
Cite
Fang CH, Sun CK, Lin YW, et al. Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model. Int J Mol Sci. 2022;23(1)doi: 10.3390/ijms23010558.
Fang, C. H., Sun, C. K., Lin, Y. W., Hung, M. C., Lin, H. Y., Li, C. H., Lin, I. P., Chang, H. C., Sun, J. S., & Chang, J. Z. (2022). Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010558
Fang, Chih-Hsiang, et al. "Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model." International journal of molecular sciences vol. 23,1 (2022). doi: https://doi.org/10.3390/ijms23010558
Fang CH, Sun CK, Lin YW, Hung MC, Lin HY, Li CH, Lin IP, Chang HC, Sun JS, Chang JZ. Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model. Int J Mol Sci. 2022 Jan 05;23(1). doi: 10.3390/ijms23010558. PMID: 35008984; PMCID: PMC8745742.
Copy Download .nbib Format: NLM
Share it on

Int J Mol Sci. 2022 Jan 05;23(1). doi: 10.3390/ijms23010558.

Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model.

International journal of molecular sciences

Chih-Hsiang Fang, Chung-Kai Sun, Yi-Wen Lin, Min-Chih Hung, Hung-Ying Lin, Ching-Hung Li, I-Ping Lin, Hung-Chen Chang, Jui-Sheng Sun, Jenny Zwei-Chieng Chang

Affiliations

  1. Trauma and Emergency Center, China Medical University Hospital, No. 2, Xueshi Rd., North Dist., Taichung City 40447, Taiwan.
  2. Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei 11221, Taiwan.
  3. Institute of Biomedical Engineering, College of Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.
  4. Institute of Biomedical Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.
  5. Department of Dentistry, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10048, Taiwan.
  6. School of Dentistry, College of Medicine, National Taiwan University, No. 1, Chang-Te Street, Taipei 10048, Taiwan.
  7. Department of Dentistry, National Taiwan University Hospital, Hisnchu Branch, No. 25, Lane 442, Sec. 1, Jingguo Rd., Hsinchu City 30059, Taiwan.
  8. Gin Chen Dental Clinic, No. 31, Long Chiang Rd., Taipei 10606, Taiwan.
  9. College of Medicine, China Medical University, YingCai Campus, No. 91, Xueshi Rd., North Dist., Taichung City 40402, Taiwan.
  10. College of Biomedical Engineering, China Medical University, YingCai Campus, No. 91, Xueshi Rd., North Dist., Taichung City 40402, Taiwan.
  11. Department of Orthopedic Surgery, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 10002, Taiwan.

PMID: 35008984 PMCID: PMC8745742 DOI: 10.3390/ijms23010558

Abstract

In this study, we fabricated gelatin/nano-hydroxyapatite/metformin scaffold (GHMS) and compared its effectiveness in bone regeneration with extraction-only, Sinbone, and Bio-Oss Collagen

Keywords: alveolar ridge preservation; bone regeneration; critical size defect; metformin; nanocomposite

References

  1. Biomed Pharmacother. 2019 Jan;109:1593-1601 - PubMed
  2. J Oral Maxillofac Surg. 2020 Nov;78(11):1953-1964 - PubMed
  3. J Endod. 2012 Jul;38(7):943-7 - PubMed
  4. Int J Mol Sci. 2019 Nov 28;20(23): - PubMed
  5. Int J Biol Macromol. 2018 Feb;107(Pt A):678-688 - PubMed
  6. Dent Res J (Isfahan). 2012 Jan;9(1):60-7 - PubMed
  7. J Am Acad Orthop Surg. 1995 Jan;3(1):1-8 - PubMed
  8. Exp Clin Endocrinol Diabetes. 2008 Jun;116(6):333-40 - PubMed
  9. Med Princ Pract. 2015;24(5):401-15 - PubMed
  10. World J Diabetes. 2016 Mar 25;7(6):122-33 - PubMed
  11. Pharmacol Res. 2016 Nov;113(Pt A):675-685 - PubMed
  12. J Tissue Eng Regen Med. 2017 Oct;11(10):2935-2949 - PubMed
  13. Arch Oral Biol. 2009 Oct;54(10):951-62 - PubMed
  14. Tissue Eng Part A. 2021 Jul 5;: - PubMed
  15. Int J Periodontics Restorative Dent. 2010 Jun;30(3):265-73 - PubMed
  16. Biomaterials. 2005 Sep;26(27):5474-91 - PubMed
  17. Toxicol Sci. 2019 May 1;169(1):34-42 - PubMed
  18. J Periodontol. 2013 Aug;84(8):1165-71 - PubMed
  19. Beilstein J Nanotechnol. 2018 Dec 27;9:3079-3094 - PubMed
  20. Biomaterials. 2020 May;239:119833 - PubMed
  21. J Clin Periodontol. 2019 Jun;46 Suppl 21:195-223 - PubMed
  22. Clin Implant Dent Relat Res. 2018 Jun;20(3):333-344 - PubMed
  23. Int J Artif Organs. 2010 Nov;33(11):765-74 - PubMed
  24. Biomaterials. 2005 Sep;26(25):5221-30 - PubMed
  25. J Tissue Eng Regen Med. 2018 Feb;12(2):437-446 - PubMed
  26. Clin Oral Implants Res. 2015 Sep;26(9):992-5 - PubMed
  27. Med Oral Patol Oral Cir Bucal. 2012 Mar 01;17(2):e356-61 - PubMed
  28. J Periodontol. 2010 Mar;81(3):412-9 - PubMed
  29. Int J Oral Maxillofac Implants. 2015 May-Jun;30(3):596-606 - PubMed
  30. J Diabetes Complications. 2010 Sep-Oct;24(5):334-44 - PubMed
  31. J Inflamm Res. 2016 Apr 11;9:27-38 - PubMed
  32. J Am Heart Assoc. 2014 Dec;3(6):e001202 - PubMed
  33. J Orthop Translat. 2015 Jun 16;3(3):95-104 - PubMed
  34. Clin Oral Implants Res. 2009 May;20(5):433-40 - PubMed
  35. Osteoporos Int. 2015 Aug;26(8):2073-89 - PubMed
  36. Int J Mol Sci. 2016 May 24;17(6): - PubMed
  37. J Endod. 2020 Jan;46(1):65-73 - PubMed
  38. Clin Oral Implants Res. 2015 Sep;26 Suppl 11:180-201 - PubMed
  39. Clin Implant Dent Relat Res. 2016 Dec;18(6):1248-1268 - PubMed
  40. Tissue Eng. 2005 Jul-Aug;11(7-8):1224-33 - PubMed
  41. J Periodontol. 2015 Jun;86(6):729-37 - PubMed
  42. J Endod. 2018 Dec;44(12):1817-1825 - PubMed
  43. J Periodontol. 2013 Feb;84(2):212-20 - PubMed
  44. J Clin Periodontol. 2014 Jan;41(1):80-5 - PubMed
  45. Clin Oral Implants Res. 2009 Jan;20(1):1-6 - PubMed
  46. Mater Sci Eng C Mater Biol Appl. 2020 May;110:110698 - PubMed
  47. Clin Oral Implants Res. 2003 Apr;14(2):137-43 - PubMed

Publication Types

Grant support